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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 13 (2022) - Issue 4, April

Review Articles

 
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1.

NEW INSIGHTS ON IN-VIVO AND IN-VITRO ANIMAL MODELS OF CEREBRAL REPERFUSION INJURY

Re-establishing blood flow in ischemia is essential for rescuing cells from necrosis in any tissue or organ. However, reperfusion post cerebral ischemia may worsen the condition and lead to “cerebral reperfusion injury”. In cerebral reperfusion injury, significant changes observed are infarct size, behavioural deficits, hematoma formation, inflammatory mediators, and oxidative stress markers t...

Y. Sreehari * and O. Prabhakar

Department of Pharmacology, GITAM Deemed to be University, Gandhinagar, Rushikonda, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1411-27

1411-1427

452

436

2.

ETHNO PHARMACOLOGICAL AND PHYTO PHARMACOLOGICAL PERCEPTION ON KALANCHOE (CRASSULACEAE) – A COMPREHENSIVE REVIEW

Natural molecules from plants are vital sources to explore potent lead molecules in the drug discovery process. Plants as A source of medicine is an ancient practice in India. The Indian subcontinent is a wide repository of medicinal plants that are being used in the traditional system of medicines. Kalanchoe is one of the medicinal plants; the succulent leaf juice is prepared by grinding the leav...

E. Selvakumari *, R. Muthukumaran, S. Atchaya, S. Kowsalya and N. Elavarasan

Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate & Research Institute of Health Sciences, Indira Nagar, Gorimedu, Priyadarshini Nagar, Puducherry, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1428-40

1428-1440

296

225

3.

TOWARDS FURTHER UNDERSTANDING THE MECHANISM OF BIOSORPTION THROUGH VARIOUS BIOSORBENTS

Biosorption is a cure to atmosphere containing heavy metals and also an alternative to physical and chemical methods used for heavy metal removal. The main aim of this review is to highlight the various mechanisms of biosorption by using various biosorbent viz. microorganisms, no-living biomass, herbal plants for the removal of heavy metals. Industrialization, globalization has provided an ease to...

Shweta Tiwari, Uma Bhardwaj and Naveen Dhingra *

Department of Bio Science, School of Liberal Arts and Science, Mody University of Science and Technology, Laxmangarh Sikar, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1441-55

1441-1455

258

152

4.

A PHYTO PHARMACOLOGICAL REVIEW ON TRADITIONAL MEDICINAL PLANT ZIZIPHUS RUGOSA LAM

Ziziphus rugosea member of Rhamnaceae family, is found in the deciduous and semi-evergreen forests of Western Ghats, India. It is commonly known as suran in Hindi. chunukoli in Urdu, badara in Sanskrit, and toran in Marathi. Z. rugosa is traditionally used in the treatment of skin diseases, mouth ulcers, dropsy, boils, diarrhea, tachycardia, syphilis, miscarriage, misconception, flatulence, hyster...

Sushma Gaikwad and Tabassum Khan *

Department of Pharmaceutical Chemistry and Quality Assurance, SVKM’s, Dr. Bhanuben Nanavati College of Pharmacy, Mithibai Campus, Vile Parle (West), Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1456-62

1456-1462

299

167

5.

AN UPDATE ON PHYTOCHEMICALS, NUTRITIONAL COMPOSITION, AND PHARMACOLOGICAL SIGNIFICANCE OF PRUNUS AMYGDALUS BATSCH: A COMPREHENSIVE REVIEW

Prunus amygdalus Batsch (family-Rosaceae), popularly known as Badam, Almond, is the most important familiar nuttree for global nut production that includes apples pears, prunes and raspberries. Almond seed skin is a prominent source of polyphenolic compounds, mainly phenolic acids, bioflavonoids, flavanones, isoflavones, flavonol glycosides and lignans that are reported in a ripened nut. Bioflavon...

Ruchi Singh, Syed Misbahul Hasan *, Akash Ved and Om Prakash

Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1463-78

1463-1478

259

134

6.

A REVIEW ON HERBAL DRUGS WITH POTENTIAL ANTI-ARTHRITIC ACTIVITY

Rheumatoid arthritis (RA) is a general inflammatory disorder touching about 1.3% of the grown-up census of the world. Over the last two decades, a significant development has been done in the thoughtfulness of RA pathophysiology, best outcomes, and successful treatment strategy, and the credit of the significance of diagnostic agents and treating RA near the beginning. Earlier than novel treatment...

Shanaz Banu and Leemol Varghese *

Dayananda Sagar University, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1479-87

1479-1487

151

92

7.

ROLE OF ROBOTICS IN HEALTH CARE SYSTEM DURING COVID-19 PANDEMIC

The essential part of robots in the medical services framework is principal limiting individual to individual contact defilement and guaranteeing cleaning disinfection. Robots can be defined as an artificially intelligent physical systems capable of interrelating with the environment. The term robot was coined from the Czech what "robota" which implies serf/worker. Robots are classified as Recepti...

K. Padmini, A. Suvarna and I. Neelam *

Department of Pharm D, CMR College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1488-98

1488-1498

124

57

8.

A REVIEW ON REGULATORY FRAMEWORK OF RADIOPHARMACEUTICALS IN PHARMACEUTICAL INDUSTRY: CURRENT SCENARIO AND FUTURE ASPECTS

In recent times, the use of radiopharmaceuticals in Medical Imaging and Nuclear medicine has increased. They are a special group of pharmaceuticals with short-shelf life in their final state, and their preparation has been done with utmost care. Due to the inherently hazardous nature of radionuclides on the one hand and the associated concern about radiation safety for patients and staff handling ...

G. Haswika Reddy * and K. Vinod Kumar

Department of Pharmaceutical Quality Assurance, Raghavendra Institute of Pharmaceutical Sciences (RIPER), Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1499-07

1499-1507

166

71

9.

BLACK TEA THEAFLAVINS: A REVIEW OF THE EVIDENCE

Tea brewed from the plant Camellia sinensis is the second most popular beverage consumed worldwide after water. The first two leaves and the leaf bud are mainly used for commercial tea production, and depending on the variation of processing techniques, it is primarily categorized into -white tea, green tea, oolong tea, and black tea. Different varieties of tea are known for their contribution in ...

Dwaipee De and Sonali Ray ⋆

Tea Chemistry & Pharmacology Laboratory, Department of Tea Science, University of North Bengal, Siliguri, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1508-23

1508-1523

127

70

10.

THE CHALLENGING ISSUES, DIAGNOSIS AND TREATMENT OF MUCORMYCOSIS-A NARRATIVE REVIEW

Mucormycosis is a new fungal disease that increased the morbidity and mortality rate in this present scenario. It's difficult to diagnose and cure due to proper scientific evidence is not yet being designed. The disease's prevalence appears to be rising. In high-income nations, hematological malignancies are the most prevalent underlying illness, while uncontrolled diabetes is usually linked to pu...

Manikantan Pappuswamy

Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).1524-32

1524-1532

114

58

11.

COMPLEX DRUG DELIVERY SYSTEMS

The majority of current drug delivery systems are existed as water-insoluble drug delivery systems but rarely water-soluble drug delivery systems. Low aqueous solubility is a common problem in pharmaceutical development. About 40% of commercialized drugs and as many as 90% of drugs in the discovery are low aqueous soluble. When given through traditional dosage forms, such drugs fail to be soluble ...

Rahul Raghav Dasari, Chinthaginjala Haranath * and Hindustan Abdul Ahad

Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), KR Palli Cross, Chiyyedu (PO), Anantapur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1533-39

1533-1539

155

76

12.

FILM FORMER IN FILM COATING

The presentation of this work aims to update professionals on issues associated with selecting the film former in the film coating process. Film coating finds applicability in a diverse field that may be for conventional (immediate) release and modified-release intended for enteric/ delayed-release or barrier membrane controlled release (extended-release). In the pharmaceutical field, film coating...

Mohammed Athar Alli Saikh

Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore, Koraput, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1540-50

1540-1550

118

66

13.

COSTUS IGNUS: INSULIN PLANT AND IT’S PREPARATIONS AS REMEDIAL APPROACH FOR DIABETES MELLITUS

Costus igneus, commonly known as insulin plant, has been traditionally reported for its anti-diabetic, anti-oxidant, anti-inflammatory, anti-proliferative, anti-urolithiasis, hypolipidemic, neuroprotective and anti-microbial activity. This review is all about anatomical and morphological investigations of Costus igneus, including its medicinal use. Secondary metabolites of this plant such as b-sit...

Sonali Shinde *, Samiksha Surwade and Rachana Sharma

Department of Pharmaceutical Chemistry, D. Y. Patil Institute of Pharmaceutical Science and Research Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1551-58

1551-1558

152

66

14.

AN OVERVIEW ON PARKINSON’S DISEASE ANIMAL MODELS: FROM CLASSIC TO EVOLVING

A progressive neurodegenerative brain disorder with motor & non-motor are signs of Parkinson's disease or idiopathic parkinsonism. Parkinsonism is characterized in striatal region by the deterioration of Substantia nigra pars compacta & dopamine depletion in Dopaminergic neurons. In Parkinsonism research, the prime purpose is to recognize the pathogenesis, strategies & implementation o...

Imtiyaz Ansari * and Sayali Shete

Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1559-66

1559-1566

109

51

Research Articles

 
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15.

EVALUATION OF ANTI-ALZHEIMER’S ACTIVITY OF ALCOHOLIC EXTRACT OF HYLOCEREUS UNDATUS FRUITS IN WISTAR ALBINO RATS

Alzheimer's is a degenerative brain disease associated with memory depletion and mild cognitive dysfunction, leading to dementia. Today's world attempts to treat various ailments have increased with medical advancements. There is still considerable research into medications capable of preventing or at least effectively altering the trajectory of AD. Medicinal plants play a major role in Alzheimer'...

R. K. Shaikh * and V. G. Kanase

Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1567-80

1567-1580

281

199

16.

ANTIOXIDANT AND ANTIDEPRESSANT ACTIVITIES OF ETHANOLIC LEAF EXTRACT OF MANILKARA ZAPOTA

Aim: The present investigation deals with the preliminary phytochemical screening, in vitro antioxidant, and in vivo antidepressant activity of ethanolic leaf extract of Manilkara zapota. Materials and Methods: In-vitro antioxidant activity was evaluated using AS free radical scavenging parameters using Hydroxyl radical scavenging assay, phosphor molybdenum antioxidant assay and NO scavenging acti...

G. V. N. Kiranmayi * and M. Sai Sureshma

Department of Pharmacology, Faculty of Pharmacy, Dr. M. G. R. Educational and Research Institute, Deemed to be University, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1581-90

1581-1590

289

171

17.

DESIGN AND IN-VITRO CHARACTERIZATION OF CHLORDIAZEPOXIDE EFFERVESCENT FLOATING TABLETS

Chlordiazepoxide is a sedative and hypnotic medication which is used to treat anxiety, insomnia, and withdrawal symptoms from alcohol and/or drug abuse. Chlordiazepoxide has a medium to the long half-life, but its metabolite is pharmacologically active and has a very long half-life. In the present work, an attempt has been made to develop effervescent floating tablets of Chlordiazepoxide. Methocel...

Haarika Balusu *, Tanvi Mathur, Yeredla Swathi, Amenah Haitham Mezher Aljubori and Sravya Maddukuri

Department of Pharmaceutics, S. N. Vanitha Pharmacy Maha Vidyalaya, Secunderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1591-97

1591-1597

308

136

18.

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE

Ondansetron hydrochloride (ONH) is an exceptionally harsh, powerful antiemetic drug utilized for the treatment and prophylaxis of chemotherapy or radiotherapy or postoperative prompted emesis. This investigation aims to detail and assesses taste-covered quick-dissolving tablets (FDTs) of ONH to expand patient consistence. ONH taste veiled granules were set up by a strong scattering procedure. Diss...

K. Muni Raja Lakshmi * and G. Asuntha

Department of Pharmaceutics, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1598-07

1598-1607

285

176

19.

DEVELOPMENT AND EVALUATION OF SILVER SULPHADIAZINE LOADED NANOFIBROUS SCAFFOLD FOR WOUND DRESSING APPLICATIONS

Electrospinning is the fiber-forming process using an electric field where electrostatic forces are employed. By this process, continuous nanofibers range from 0.01 to 10 micrometers can be obtained. Nanofibers produced by the electrospinning technique has application in various fields such as tissue engineering, wound dressing, filtration, protective clothing, drug delivery, and sensor applicatio...

Liby Tresa Francis * and A. J. Chacko

Pushpagiri College of Pharmacy, Tiruvalla, Pathanamthitta, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1608-15

1608-1615

247

125

20.

FORMULATION AND EVALUATION OF CANDESARTAN CILEXETIL LOADED SOLID LIPID NANOPARTICLES WITH IMPROVED BIOAVAILABILITY

In this present work, BCS class II Candesartan celexitil, as an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure, was successfully loaded in the solid lipid nanoparticles (SLNs) by using hot high-speed homogenization method. The SLN formulations were prepared and optimized by Box Benhken design study. The SLN was characterized by Nanoph...

U. S. Bagul *, A. A. Tagalpallewar and A. A. Kshirsagar

Department of Pharmaceutics, Sinhgad Technical Education Society, Narhe, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1616-23

1616-1623

102

47

21.

ADVANCEMENT OF GLYCOSIDE HYDROLASE PRODUCTION FROM BACILLUS CEREUS KKSJ 1981 BY STATISTICAL METHOD OF OPTIMIZATION

Pullulanase (Pullulanase-α-glucanohydrolase EC 3.2.1.41) is a glucanohydrolase enzyme that can break down the pullulan and allied oligosaccharides into glucose. Promising of starch-based industries are biofuels, starch syrup, nutraceuticals, etc., increase the glucanohydrolases demand. Present investigation revealing that the Bacillus cereus KKSJ 1981 is enhanced the production of pullulanase thr...

Siva J. Jyothi *, Emandi Hemalatha and Kishore K. Kumar

Hindu college of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1624-31

1624-1631

97

50

22.

DRUG UTILISATION PATTERNS, PREVALENCE OF RISK FACTORS, OPPORTUNISTIC INFECTIONS AND QUALITY OF LIFE AMONG HIV PATIENTS IN A GOVERNMENT HOSPITAL IN BHIMAVARAM

Objectives: To assess the risk factors, opportunistic infections (OI’s), prescribing patterns along with ADRs, medication adherence, and quality of life (QoL) among HIV patients. Methods: This is an Ambi-directional cohort study conducted at the Government hospital, Bhimavaram, for 6 months from July 2019 to December 2019, including 201 HIV patients’ data. The data were analyzed using GraphPad...

Roopa Pravallika Koduri, Akhila Kombathula, Kumar V. S. Nemmani, Jakka Venkata Srinivas and Anil Kumar Sagi *

Department of Pharmacy Practice, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1632-39

1632-1639

106

65

23.

EVALUATION OF ANTI-DEPRESSANT EFFECT OF ACACIA NILOTICA LINN LEAVES EXTRACT IN EXPERIMENTAL ANIMALS

A chronic illness that affects a person's mood, thoughts, physical health, and behavior patterns is considered depression. Currently used anti-depressant drugs such as selective serotonin reuptake inhibitors (SSRI) and tricyclic anti-depressants (TCA) are showing various side effects and thus, the search for a new anti-depressant herb without side effects is important. The intend of the present st...

Manish Kumar Shakya *, Arif Naseer and Ranjit Singh

Department of Pharmacology, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1640-46

1640-1646

101

65

24.

DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING HPTLC ASSAY METHOD OF REMOGLIFLOZIN ETABONATE IN BULK AND MARKETED FORMULATION

Remogliflozin Etabonate (RE) is the latest addition to the sodium-glucose transport proteins 2 inhibitor class of drugs recently approved in India to manage type 2 Diabetes Mellitus. Literature survey revealed that no high-performance thin-layer chromatographic (HPTLC) method had been reported to date for this drug. The present work describes the development and validation of an HPTLC method for R...

Sushant Ahire and Aishwarya Balap *

PES’s Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).1647-56

1647-1656

102

73

25.

EVALUATION OF ANTI-ALZHEIMER’S ACTIVITY OF ALCOHOLIC EXTRACT OF CISSUS QUADRANGULARIS STEMS IN WISTAR ALBINO RATS

Alzheimer's disease is the most frequent cause of dementia worldwide and its incidence is increasing due to the world's aging population. Alzheimer's disease (AD) is one of the greatest medical care challenges of our century and is the main cause of dementia and neurodegenerative diseases. Dementia is defined as an acquired loss of cognition in many cognitive domains. Herbal medicine has evolved a...

Shilpa S. Sarvagod * and Vanita G. Kanase

Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1657-69

1657-1669

113

61

26.

A COMPARATIVE STUDY OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DICLOFENAC SODIUM IN SOME GENERIC AND BRANDED DRUGS

Pain is the most common symptom of disease, which accompanies us from an early age. It is a safeguarding mechanism of the body from harmful stimuli. The definition of pain states that it is a subjective sensory and emotional experience. This study compared generic and brand drugs' analgesics and anti-inflammatory activity using eddy’s hot plate method and plethysmometer models. Two studies were ...

Suranjan Bantupalli, Atluri Deekshit, Bala Yaswanth S. Kumar, Radha B. Madhavi and Kanaka Durga Devi Nelluri *

KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1670-79

1670-1679

112

64

27.

GAS CHROMATOGRAPHIC DETERMINATION OF FATTY ACID COMPOSITION IN COCONUT OIL EXTRACTED BY PROBE SONICATION TECHNIQUE

Coconut oil is an edible vegetable oil used in the food, pharmaceuticals, and cosmetics industries. Fatty acids are the major constituents of Coconut oil. Various methods were reported for the extraction of oil from coconut seed kernels. Extraction of coconut oil from its seed kernel using the probe sonication method is not reported in the literature. Hence, in the present study, oil was extracted...

Rajasekaran Aiyalu *, Dharshan Unni, Arivukkarasu Ramasamy and Shalini Sivadasan

Department of Pharmaceutical Analysis, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1680-87

1680-1687

102

52

28.

FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF CIMETIDINE FOR ITS GASTRO RETENTIVE DRUG DELIVERY EFFICACY

The Aim and objective of this work were to build up a gastro retentive drug delivery system. Cimetidine is used as a model drug for making mucoadhesive dosage forms. The formulation can be achieved by using the ionic gelation method. The model drug used in this work plan is categorized in antiulcer treatment. The extended-release mucoadhesive microspheres of the drug provide constant plasma concen...

K. M. Nidhi *, Sanjar Alam, K. M. Uma, Naveen Sharma, Jaya Bhati and Sarita Prajapati

Department of Pharmacy, J. K. Institute of Pharmacy, Bulandshahar, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1688-94

1688-1694

108

62

29.

EFFECT OF SUGARCANE BAGASSE AS A SOURCE OF CARBON FOR ɑ-AMYLASE ENZYME AND ANTIBACTERIAL COMPOUND PRODUCING DIFFERENT TYPES OF WILD FILAMENTOUS FUNGI

The present investigation screening and characterization of α-amylase and antimicrobial compound producing filamentous fungi is used for extensive commercial applications in various sectors and is highly demanded in the Biotech industry. The results reveal that out of the carbon substrates alone, sugarcane bagasse with a combination of Tween-80 was found to yield maximum α-amylase (151.76 IU) un...

A. Kalaiyarasan, S. Roobamathy, B. Vijayaraghavan, R. Lakshmi Sundaram and N. Hariram *

Department of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1695-07

1695-1707

102

59

30.

EVALUATION OF ANTIFUNGAL PROPERTY AND PHYTOCHEMICAL ANALYSIS OF UNDEREXPLOITED LEAFY VEGETABLES

The adverse environmental impact of fungicides used in plant disease control is escalating day by day. Generally, plant diseases are controlled by synthetic fungicides, chemical methods, and bio-control agents. Chemical methods lead to deterioration of soil fertility and cause pollution. Being highly stable and resistant to biodegradation, chemical fungicides also enter the food chain and are resp...

P. Sona Peter *, P. Sainamole Kurian and S. Karthika Menon

Department of Botany, Vimala College, Thrissur, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).1708-14

1708-1714

127

60

31.

WOUND HEALING EFFICACY OF A POLYHERBAL TOPICAL GELIN RAT MODELS OF EXCISION WOUND, INCISION WOUND, AND THERMAL BURN INJURY

Background: In Ayurvedic literature, Aloe vera, turmeric, honey, karanj oil, and cow ghee are documented for medicinal properties like anti-infective, anti-inflammatory, anti-oxidant, anti-coagulant and wound recovery. Objective: In this study, we aimed to evaluate the efficacy of a topical gel containing Aloe vera extract, turmeric, honey, karanj oil, and cow ghee for wound healing. Methods: Topi...

Eyaldeva C. Vijayakumar, Neha Desai, Munira Momin, Sailee Kadam, S. S. Gandhi and Lokesh Kumar Bhatt *

SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, VileParle (West), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1715-25

1715-1725

99

51

32.

PREPARATION AND IN-VITRO EVALUATION OF 0.05% 5-FLUOROURACIL SOLID LIPID NANOPARTICLE GEL IN THE TREATMENT OF ACTINIC KERATOSIS

The present study focused on the formulation and in-vitro evaluation of 0.05% 5-fluorouracil solid lipid nanoparticle gel in treating actinic keratosis. The in-vitro release profile of solid lipid nanoparticle gel is higher than the marketed cream formulation; thus, we can reduce the dose of formulation by this method. This is prepared using tween 80, tween 20, glycerol monostearate, glycerol, and...

B. Aswathy *, Remya Ravindran, R. P. Ramkumar and Labeeb Apaduvanpadavath

Department of Pharmaceutics, KTN College of Pharmacy, Chalavara, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1726-37

1726-1737

94

61

33.

FORMULATION OF NANOSTRUCTURED BASED DELIVERY SYSTEM OF FISET IN FOR SKIN CANCER

The research work is focused on the formulation of dermal drug delivery system of Fisetin. The formulation based on the principal to causes deeper skin penetration and minimal systemic delivery for the management of skin cancer by enhancing the dermal bioavailability of formulation with reducing dosage requirement in sustained delivery mode by direct targeting of formulations to the skin. Two form...

Priyanka Gupta, Rajneesh Kumar * and Kalpana

Kanpur Institute of Technology & Pharmacy, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1738-46

1738-1746

98

57

34.

GLUTATHIONE AND ANTIOXIDANT STUDY IN TESTES OF WISTAR RATS AFTER DIETARY COPPER DEFICIENCY

Copper is an essential trace element involved in a plethora of functions being a component of several enzymes. Copper deficiency affects people of all age groups, including infants, children, pregnant women, and men. Deficiency occurs due to numerous factors hindering the absorption/uptake of copper. Male Wistar rats (35-50 gm) were divided into four groups: Group 1: Negative control – fed with ...

Aastha Saini, Ankita Rajendra Kurup and Neena Nair *

Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1747-54

1747-1754

111

58

35.

KNOWLEDGE OF ANTIMICROBIAL RESISTANCE AND ANTIMICROBIAL PRESCRIPTION AMONG DENTAL PRACTITIONERS IN CHENNAI CITY- A CROSS-SECTIONAL STUDY

Introduction: Most human oro-facial infections originate from odontogenic infections, and prescribing antimicrobial has become a ubiquitous phenomenon. The World Health Organization (WHO) has recognized the inappropriate, indiscriminate and irrational use of antimicrobials leading to antimicrobial resistance. Aim & Objective: To assess the knowledge of antimicrobial resistance and antimicrobia...

C. Rajkumar *, P. Iyapparaja, Parangimalai Diwakar Madankumar and Swetha Gadde

Department of Public Health Dentistry, Ragas Dental College and Hospital, 2/102, East Coast Road, Uthandi, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).1755-64

1755-1764

101

51

36.

IN-VITRO ANTIDIABETIC AND ANTIOXIDANT ACTIVITIES OF AQUEOUS AND ETHANOLIC EXTRACT OF VITIS VINIFERA SEEDS

In the present study, the aqueous and ethanolic extracts of Vitis vinifera seeds were studied for alpha-amylase and alpha-glucosidase inhibition using an in-vitro model. The plant extracts were also examined for their antioxidant activities by using the free radical 1, 1-diphenyl-2-picryl hydrozyl (DPPH) scavenging method under in-vitro. The study revealed that the different concentrations of the ...

R. Gomathi *, K. Nithyasri, J. Roshika, K. Subhapathi and P. Priyadharshini

Department of Biochemistry, Holy Cross College, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1765-70

1765-1770

105

52

37.

ANTI-CANCER EFFECT OF PANCHAGAVYA ON HUMAN COLON ADENOCARCINOMA (HCT-116) CELL LINE

The objective of the study was to investigate the in-vitro anti-cancer effect of Panchagavya on the Human Colon Adencarcinoma (HCT-116) cell line. Panchayavya was formulated using five products from Cows, namely; Cow dung, Cow urine, Cow milk, Cow curd and Cow ghee. The whole mixture was further freeze-dried and stored until further assay conduction. The growth inhibitory activity of the raw Panch...

S. Funde, S. Patil * and H. Palep

Principal K. M. Kunanani College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1771-76

1771-1776

301

77

38.

SYNTHESIS AND ANTI-CONVULSANT ACTIVITY OF NOVEL BENZHYDRYL PIPERAZINE DERIVATIVES

A series of 1 - (4 -Benzhydryl piperazin-1-yl) -3-(mono -substituted) propan-1-one (7c-i) and N - (substituted) - 2 - (4 –benz-hydrylpiperazin – 1 - yl) acetamide (7a, 7d) were designed, synthesized and evaluated for their anticonvulsant and neurotoxicity activity. The chemical structure of the synthesized compounds was elucidated by spectral and elemental analysis. Compounds like 7d, 7c, and ...

Kuldeep Singh *, Ashok K. Shakya, Shashi Alok, Rajashri R. Naik and Arun Kumar

Faculty of Pharmacy, Integral University Kursi Road, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(4).1777-84

1777-1784

99

58