A COMPARATIVE SOLUBILITY ENHANCEMENT AND DISSOLUTION STUDY OF RANOLAZINE USING DIFFERENT TECHNIQUES

The aim of the present study was to enhance the solubility of the poorly soluble drug Ranolazine. Solid dispersions were prepared using PVP K-30 and PEG 4000 & 6000 by melting, solvent evaporation using varying polymer ratios (1:1, 1:2, 1:3, 1:4). The prepared formulations were characterized for saturation solubility, IR, PXRD, SEM. The aqueous solubility of Ranolazine was favored by the presence of polymers. In contrast to the very slow dissolution rate of pure Ranolazine, amorphous solid dispersions considerably improved the dissolution rate. PXRD, DSC, SEM studies confirmed the amorpicity of Ranolazine. The saturation solubility of pure drug RN was found to be 0.142mg/ml, whereas that of SD4 was found to be 0.77mg/ml. The drug release of the pure drug was 28.70% at the end of 3 hours and the drug release was found to be enhanced in SD4 that is 96.44% and SD8 is 84.85%. The formulations SD4 and SD8 showed the highest solubility and dissolution rate. This can be attributed to the increased wettability and dispersibility of Ranolazine in polymeric matrix as well as decreased crystallinity and increase in amorphicity. Stability study confirmed that there is no recrystallinity of drug over storage for a specific period.