A COMPREHENSIVE REVIEW ON ACNE, ITS PATHOGENESIS, TREATMENT, IN-VITRO AND IN-VIVO MODELS FOR INDUCTION AND EVALUATION METHODS

Acne is a common inflammatory disorder which is common among the adolescent age groups. Even though it is not a life-threatening disease but it affects the patient’s self-esteem. Additionally, they have also gone into depression and suicidal ideation. Based on the severity it can be classified into several types. Various factors are responsible for the occurrence of acne. The main factors are discussed in this article. According to the Global Burden of Disease study about 85% of the populations are being affected when we consider the epidemiology. Among this, the Americans are most prone to it. A variety of medications are available in the market for the treatment of acne like retinoid derivatives, benzoyl peroxide, and antibiotics etc. Among which the topical treatment is most preferred. Other treatments are carried out only if the existing treatment doesn’t give the desired results. Nanotechnology has also been incorporated for the existing drug in order to target the disease. Acne can be induced in the animal. Existing works of literature gives information on how to induce acne in an animal by using bacteria as well as chemical. Different in-vitro and in-vivo studies exist to determine several aspects of the drug. In this article, we have focused on all the above topics in brief.