A COMPREHENSIVE REVIEW ON BENZOTHIAZOLE DERIVATIVES FOR THEIR BIOLOGICAL ACTIVITIES
AbstractBenzothiazole derivatives have a wide interest because of their diverse biological activities and clinical use. This bicyclic compound consists of a fusion of benzene nucleus with a five-membered ring comprising nitrogen and sulphur atoms. It is a vital Pharmacophore and privileged structure in medicinal chemistry and exhibits various useful therapeutic activities such as anti-tubercular, antimicrobial, antimalarial, anticonvulsant, anthelmintic, anti-inflammatory, anti-tumor, anti-diabetic, analgesic, neurodegenerative disorders, local brain ischemia, and central muscle relaxant activities. Moreover, it can be easily found in a range of marine or terrestrial natural compounds that have tremendous biological activities. Benzothiazoles have a promising biological profile and are easy to access which makes this pharmacophore an interesting molecule for designing new bioactive benzothiazole derivatives.
Article Information
7
3196-3209
978
1715
English
IJPSR
S. Abrol, R. B. Bodla * and C. Goswami
Department of Pharmaceutical Chemistry, Delhi Pharmaceutical Science and Research University, Delhi, New Delhi, India.
rameshbodla@gmail.com
23 October 2018
07 February 2019
08 March 2019
10.13040/IJPSR.0975-8232.10(7).3196-09
01 July 2019
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