A COMPREHENSIVE REVIEW ON OSMOTICALLY CONTROLLED ORAL DEVICEAbstract
The most well-known widely used route of administration among all the routes that have been explored for the systemic delivery of drugs is oral drug delivery. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. The osmotic-controlled release oral delivery system, OROS, is an advanced drug delivery technology that uses osmotic pressure as the driving force to provide pharmacotherapy, usually once daily, in several therapeutic areas. This system is independent of the physiological factors of the gastrointestinal tract and can be utilized for systemic as well as targeted delivery of drugs. Osmotic pumps consist of a core coated with a semi-permeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. It mostly consists of three things a semi-permeable membrane, a core, and a delivery orifice. This paper highlights the principle of osmosis, materials used for the fabrication of pumps, types of pumps, advantages, disadvantages, and marketed products of this system. This review brings out new technologies, fabrication, and recent clinical research in osmotic drug delivery. Overall, oral osmotically driven systems appear to be a promising technology for product life-cycle strategies.
P. Banerjee * and T. K. Satpathy
Gupta College of Technological Sciences, Asansol, West Bengal, India.
23 December 2019
10 September 2020
18 September 2020
01 October 2020