A NEW RS HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IMPURITIES IN LOSARTAN POTASSIUM IN PHARMACEUTICAL DOSAGE FORM
AbstractLosartan is used for hypertension, including in people with left ventricular hypertrophy (enlarged heart muscle), and kidney dysfunction among type II diabetics. It may also delay progression of diabetic nephropathy. It is a suitable pharmacological agent for the reduction of renal disease progression in patients with type 2 diabetes, hypertension, and microalbuminuria (>30 mg/24 hours). A Related Substance High Performance Liquid Chromatography method has been developed and validated for Losartan Potassium. Chromatographic separation of the pharmaceutical was performed on an Inert Sil ODS 3V column (5µm 4.6 mm×250 mm) with a 250:50:2 (v/v) mixture of acetonitrile, methanol and Triethylamineas mobile phase, at a flow rate of 1.0 mL min–1, and detection at 237 nm. Separation was complete in less than 20 min. The method was validated for linearity, accuracy, precision, limit of quantitation, and robustness. Linearity, accuracy, and precision were found to be acceptable over the ranges 50–150.00 g mL–1 for Losartan Potassium.
Article Information
16
980-985
615 KB
48
English
IJPSR
Shailendra V. Dalvi *, Gurunath V. Pandit, Prashant J. Lokhande and Omkar D. Kinjawadekar
Quantitative Quality Chemistry, Chikitsak Samuha’s Patkar-Varde College, Goregaon, Mumbai, Maharashtra, India.
ggundipatkarvardecollege@gmail.com
12 November 2024
02 December 2024
13 December 2024
10.13040/IJPSR.0975-8232.16(4).980-85
01 April 2025
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