A NOVEL SUSTAINED RELEASE ROBUST MATRIX PELLETS OF GLIPIZIDEAbstract
Multiparticulate drug delivery system are mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some amount desired characteristics such as pellets.The purpose of present study was to prepare sustained release robust matrix pellets of Glipizide. The study revealed successful application of factorial design, optimization of extrusion spheronization process, and sustaining release of Glipizide for formulating uniform, spherical Glipizide pellets. Speed and time of spheronization is critical parameter for optimum sphericity. The Optimum speed and time of operating spheronization is 1350 rpm and 15 min. The results of this study showed that combination of HPMC K100M LVCR as hydrophilic matrix polymer and PEG 400 as potential plasticizer is effective and useful for sustaining the Glipizide release to treat diabetes mellitus. The in-vitro studies showed Q16 at approximately 80% cumulative release in case of F4, F5, F6, It indicates that this system can sustain the release upto 24 h which is desirable for sustained release specificity. Although, the hydrophilic matrix polymer optimization is critical for drug release, this study suggests the promising approach for formulation of sustained release robust matrix pellets of Glipizide.
P. K. Puranik, S. D. Pol *, S. B. Patil, N. G. Ransing, P. S. Ramteke, B. A. Patil, P. K. Khobragade and R. G. Palaskar.
Department of pharmaceutics, Government College of pharmacy, Aurangabad-431005, MH, India.
24 May, 2014
26 July, 2014
16 September, 2014
01 January, 2015