A REVIEW ON DIABETIC PERIPHERAL NEUROPATHY: PATHOPHYSIOLOGY, DIAGNOSIS AND PHARMACOTHERAPY
AbstractDiabetic Peripheral Neuropathy (DPN) is a prevalent and debilitating complication of diabetes mellitus, impacting the global well-being of millions. This review provides a concise overview of the key aspects related to DPN, including its pathophysiology, diagnostic approaches, and current pharmacotherapeutic interventions. The pathophysiology involves intricate mechanisms driven by hyperglycemia-induced oxidative stress, inflammation, and metabolic dysfunction, resulting in peripheral nerve damage. Diagnosis relies on a combination of clinical and electrophysiological assessments. Pharmacotherapy, a pivotal component in DPN management, encompasses analgesics, anticonvulsants, and neurotrophic agents, aiming to alleviate symptoms and impede disease progression. The abstract underscores the need for a multidisciplinary approach and ongoing research to enhance the understanding and treatment of DPN, ultimately improving the quality of life for individuals affected by this complication.
Article Information
10
1983-1990
498 KB
160
English
IJPSR
Minol Vijayan * and Praseena Kotheri
Department of Pharmacology, National College of Pharmacy, Manassery, Mukkam, Kerala, India.
minol1980@gmail.com
04 January 2024
20 February 2024
16 April 2024
10.13040/IJPSR.0975-8232.15(7).1983-90
01 July 2024
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