A REVIEW ON OBESITY AND ITS REGULATORY HORMONESAbstract
Obesity is related with a number of metabolic difficulties, growing obesity may disrupt hormonal and metabolic systems, which may lead to the body storing extra energy in a variety of forms. The amount of total energy the body has stored as fat is negatively associated with the rate at which leptin circulates in the bloodstream, which is predominantly produced by adipose tissue. It is widely accepted that central serotonin contributes to the inhibition of hunger in mammals and recent reviews have elucidated the mechanisms behind these effects. The hypothalamus regulates hunger as well as energy homeostasis. The digestive tract and adipose tissues are just two examples of peripheral afferent signals that complex brain networks combine to create efferent responses that regulate food intake and energy use. Origin of ghrelin in the circulation is the abdomen and gut. Dopaminergic circuits are used to control intake of food, according to research on human brain imaging. According to the carbohydrate-insulin paradigm, adipose tissue’s endocrine dysregulation rather than acting as a passive fat-accumulator as a result of overeating is the primary source of positive energy balance. Studies on mice and rats show that GLP1RA enhances energy expenditure, which results in the reduction in weight in preclinical testing. GLP-1 has considerable and powerful effects on gastric acid production and stomach emptying.
Siddharth Jain * and Snigdha Das Mandal
Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, P.O. Limda, Waghodia, Vadodara, Gujarat, India.
02 January 2023
20 March 2023
30 May 2023
01 September 2023