A REVISED RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF VILDAGLIPTIN AND PIOGLITAZONE HCl – APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS
AbstractA simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-diabetic drugs. The separation was achieved on ACE 3 150mm*4.6mm, 3.5µm column with gradient flow. The mobile phase at a flow rate of 1.5 mL min−1 consisted of 10mM sodium hexane sulphonate monohydrate and 10mM Potassium dihydrogen phosphate buffer with acetonitrile and methanol in gradient ratio. The UV detection was carried out at 210 nm. The method was successfully validated in accordance to ICH guidelines. Further, the validated method was applied for commercially available pharmaceutical dosage form
Article Information
47
847-855
1017KB
2285
English
IJPSR
Hitesh P. Inamdar *, Ashok A. Mhaske , Shirish P. Sahastrabudhe
Research Officer, Getz Pharma Research Pvt. Ltd., , Mumbai, Maharashtra, India
hitesh.inamdar@gmail.com
05 November, 2012
21 December, 2012
29 January, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).847-55
01 February, 2013
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