A STUDY ON DRUG DOSE ADMINISTRATION IN GERIATRICS WITH RESPECT TO CREATININE CLEARANCE RATE

Objective: The objectives are to assess the drug dose administration and reduce the dose toxicity in geriatric patients. Method: A Prospective interventional study has been carried out on drug dose administration in geriatric patients with respect to creatinine clearance rate at a tertiary care hospital for about 6 months. A total number of 204(47 baseline+157study) geriatric patients are included who has attended the general medicine ward. Results: In our study, we observed that Creatinine clearance was decreased as age increases. In study population 60-65yrs (48.6ml/min) was more, in 80-85yrs (29.2ml/min) was less and also similar in baseline study. So we can understand that geriatrics has  a moderate renal failure. In a baseline among 47 subjects, 53% require dose modifications. In baseline 11 (44%) subjects experienced adverse drug reactions. Mostly Augmented types of adverse effects were observed. Among 157 study population, 28% were undergone dose modification by the suggestion of a pharmacist. It was observed that in 31 (70.4%) dose of the drug was reduced, in 6(13.6%) dose interval was increased, in 7(16%) both dose and dose interval was changed. Among the study population, 8(18%) were experienced adverse drug reactions. As compared to baseline, in study population the adverse drug reactions and dose burden on the renal system is reduced. Conclusion: The geriatric patient’s creatinine clearance was decreased with respect to the age. It was observed that dose modifications were needed based on Creatinine clearance in geriatrics. The clinical outcome of the patient was improved, and adverse effects were reduced after dose modification. Pharmacist intervention plays a pivot role in avoiding drug-related problems and improves the quality of life.