A STUDY ON FEASIBILITY OF OPTIMIZATION TECHNIQUE IN FORMULATION OF DISPERSIBLE TABLETS BY FACTORIAL DESIGNAbstract
In the present research work an attempt was made to study the effect of formulation variables in the development of dispersible tablet by using various super disintegrants. Instead of normal trial and error method an optimization technique was adapted. Amount of Crosscarmellose sodium, SSG and MCC were included as independent variables and hardness, percentage friability, disintegration time and wetting time were considered as dependent variables. The study was conducted separately for Starch and CPVP as binders. The post compression parameters like hardness, percentage friability, disintegration time and wetting time were found to be within the permissible limits of IP. The results were fitted to quadratic and linear model and were found to be significant. For the selection of optimized formulation a numerical optimization by desirability function was performed with desired constraints. The optimized tablet formulations contained 10.79mg of Crosscarmellose sodium and 1.21mg of MCC for starch as binder and 3.38mg of SSG with 8.62mg of MCC for CPVP as binder. Observed results were in close accord with the predicted values of the optimized formulations, and consequently demonstrate the feasibility of the optimization procedure in the development of dispersible tablets.
R.E. Ugandar*, Kiran C. Nilugal, Nagarajan Srinivasan and Nagashekhara Molugulu
Faculty of Pharmacy, Asia Metropolitan University, G-8, Jalan Kemacahaya, Taman Kemacahaya, Batu 9, Cheras- 43200, Selangor, Malaysia
24 October, 2013
28 February, 2014
26 March, 2014