A STUDY ON TERNARY MIXTURE OF PEPTIDE USING ULTRASONIC, IN-VITRO AND IN-SILICO PROCESSESAbstract
Penetrating biomolecules by ultrasonic techniques is an innovative and influential tool for characterizing their physicochemical properties. Peptides have been used as extensive applications in drug construction and as an ingredient in nutritional complements. An investigation based on the behavior of the promulgation of ultrasonic waves in solids and the liquid system is now rather well recognized as an effective means for scrutinizing certain physical properties of the materials. The data attained from ultrasonic proliferation parameters such as ultrasonic velocity, density, viscosity, etc. and additional variation with a concentration of one of the modules of a medium are useful in consideration of the nature of molecular interaction in terms of physical parameters. Owing to the sensitivity to very low populace densities at high energy circumstances, ultrasonic methods have been preferred and are testified to be corresponding to other techniques. An exhaustive study of literature exposes that the ternary solutions and liquid mixtures were premeditated and reported by different inventors. They testified on the nature of forces elaborate in the formation of the hydrogen bonds. The research work on peptide with a fixed concentration of drug at 298.15 K to 318.15 K system is scanty. Further, to exhibit the biological activity of the non-aqueous solutions, molecular docking (ligand-protein) inspirations are performed by consuming Auto Dock 4.2.6 tools, and their binding energy, hydrogen bond lengths values are determined. The increasing trend in thermodynamical parameters indicates strong peptide-drug-amide molecular interactions captivating in the non-aqueous solutions. The attained ultrasonic results are correlated with antimicrobial and molecular docking studies.
R. Padmavathy *, K. Dhanalakshmi and R. Geetha
PG & Research Department of Physics, Seethalakshmi Ramaswami College, Tiruchirappalli, Tamil Nadu, India.
17 October 2019
02 April 2020
25 August 2020
01 October 2020