A STUDY TO EVALUATE THE IN VITRO ANTIMICROBIAL ACTIVITY AND ANTIANDROGENIC EFFECTS ON RATS OF Cr (III) COMPLEXES OF S∩N DONOR LIGANDS

The present paper deals with synthesis and characterization of some new chromium (III) Schiff base complexes using microwave irradiation technique as well as conventional heating. The S^∩N donor benzothiazolines, 1-(2-furanyl) ethanone benzothiazoline (Bzt₁N^∩SH), 1-(2-thienyl) ethanone benzothiazoline (Bzt₂N^∩SH) and 1-(2-pyridyl) ethanone benzothiazoline (Bzt₃N^∩SH) were prepared by the condensation of ortho-aminothiophenol with respective ketones in ethanol. The chromium (III) complexes have been prepared by mixing CrCl_3∙6H₂O in 1:1 and 1:2 M ratios with benzothiazolines. The structure of the ligands and their transition metal complexes were confirmed by the elemental analysis, melting point and molecular weight determinations, IR, ¹H NMR, electronic, EPR spectral studies. On the basis of these studies an octahedral environment around the chromium (III) ionhas been proposed. The in vitro antimicrobial and in vivo antifertility activities of Schiff base ligands and their respective chromium (III) complexes were performed on pathogenic bacterial and fungal strains and male albino rats respectively. The results indicated that the complexes showed higher activity than the parent ligands.