Pages Menu
ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

Categories Menu

A SURVEY ON ANTICANCER PROPERTIES OF INDIAN MEDICINAL PLANTS – A BROAD SPECTRUM ANALYSIS

HTML Full Text

A SURVEY ON ANTICANCER PROPERTIES OF INDIAN MEDICINAL PLANTS - A BROAD SPECTRUM ANALYSIS

K. Saranya, V. Manivasagan, R. Kanakadurga, V. P. Mohan Babu * and N. G. Ramesh Babu

Department of Biotechnology, Adhiyamaan College of Engineering (Autonomous), Hosur - 635109, Tamil Nadu, India.

ABSTRACT: Several plants across the world possess specific therapeutic and diagnostic properties. The identification of the properties among them is the most difficult task. Several researchers have used several methodologies to express the therapeutic properties in the plants. The interest of scientists among the anticancer studies has been increasing widely as cancer has become one of the deadliest diseases. The usage of different parts of the plant and using the different extracting solvents has shown effective results on different types of cancer cell lines. Several plants synthesize metabolites which possess anticancer properties that have been used in the development of drugs by clinical trials. The application of nanoparticles from plants in cancer treatment has been regarded as a successful method recently. The present review aims at the study of a broad spectrum of plants having anticancer properties using the in-vitro analysis of particular cell lines. The anticancer activity was analyzed by different assays such as MTT assay, “Alamar Blue” Resazurin reduction assay, SRB assay, and WST-1 assay. The results were calculated based on absorbance values. Thus, the potential of the plant extract against specific cancer cell line was evaluated.

Keywords:

Plant extracts, Cell lines, MTT assay, Resazurin reduction assay, SRB assay, WST-1 assay

INTRODUCTION: Cancer is one of the five leading causes of death in the world 1. Cancer is the abnormal, uncontrolled division of cells in the body 2. The cancer cells when malignant, invade various parts of the body through the bloodstream. Men are mostly affected by lung cancer, colon cancer, rectum, and prostate cancer. Women are mostly affected by breast, colon, rectal and stomach cancer 3. Every year, millions of people are affected by cancer, leading to death 4. It is estimated that by 2030, there will be 17 million deaths caused by cancer 5.

The cancer patients can be treated by some methods such as chemotherapy, radiotherapy and chemically derived drugs 6. Among the methods, chemotherapy is the most used treatment used for curing the advanced stages of cancer. Apart from treating the cancer cells, it also produces toxicity to the normal cells 7.

Cancer can be broadly classified into carcinoma, sarcoma, melanoma, lymphoma, and leukemia. Carcinomas include almost 81% of overall cancer available, which originate in the skin, lungs, breasts, pancreas, and other organs and glands. Lymphomas are the cancers of lymphocytes. Leukemia is the form of cancer in blood. Sarcomas occur in bone, muscle, fat, blood vessels, cartilage, or other soft or connective tissues of the body. Melanomas are cancers that arise in the cells that make the pigment in the skin. Cancer has been recognized for thousands of years as a human ailment, yet only in the past century has medical science understood what cancer is and how it progresses. Cancer specialists, called oncologists, have made remarkable advances in cancer diagnosis, prevention, and treatment. Today, more people diagnosed with cancer are living longer. However, some forms of the disease remain frustratingly difficult to treat. Modern treatment can significantly improve the quality of life and may extend survival. According to the WHO, more than 80% of the population in the developing countries are dependent on traditional medicine for treating cancer 8. According to statistics, 60% of the drugs for treating cancer derived from plants 9. More than 3000 plants have anticancer activity 5. India is one among the 12 centers in the world that contain a diversity of plant producing novel bio-molecules 9. India is known as “the botanical garden of the world” and is the highest plant producer of the world 10. The main rationale of the review is to study the in-vitro anticancer activity of different plants available in a broad spectrum survey.

Extraction: The extracts from different parts of the plants such as leaves, fruits, stems, shoot, bark, flowers, roots, and rhizome were used for the analysis of anticancer properties. Soxhlet extraction apparatus was preferred by researchers for extraction. One among the following assays was used for the anticancer activity.

In-vitro Anticancer Activity:

MTT Assay: [3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide] MTT colorimetric assay is the mostly used assay for anticancer activity. In this assay, the extracts were made to be dissolved in (dimethylsulfoxide) DMSO along with diluted cell culture media. Initially, the cells taken from the cell lines were counted. The cells were diluted and seeded in 96 well microtiter plates. This was kept for incubation. The absorption was measured and the cell viability was calculated 11.

“Alamar Blue” Resazurin Reduction Assay: In Resazurin reduction assay, the cells of cell lines were suspended in DMEM. This was seeded in 96-well plate at dilution. The plant extracts were made to be serially diluted along with the medium and supplied to the cells. This was kept for incubation. Following incubation, fresh media along with Resazurin was added and again incubated. The fluorescent intensity of dye was measured as a result of the cytotoxic activity of the cells 12.

SRB Assay: RPMI 1640 medium containing fetal bovine serum was selected, and the diluted cells were inoculated to 96 well plates. This was kept for incubation. The extract was then added and again incubated. The assay was then completed by the addition of TCA to the cells. Then the cells were finally added to the SRB solution. The absorbance was read 13.

WST-1 Colorimetric Assay: WST-1 (4- [3- (4-iodophenyl)-2 -(4-nitrophenyl) -2H-5-tetrazolio]-1, 3-benzene disulfonate) colorimetric assay was performed by incubating the inoculated cells to the 96 well plates along with the media. After incubation, appropriate concentrations of the extracts were made to be added. This was again incubated. The cells and the extract were solubilized in DMSO, and an appropriate quantity of WST-1 was added. The absorbance was calculated 14.

In-vitro Anticancer Activity of Medicinal Plants: Some of the plants that exhibit anticancer activity are given in Table 1.

TABLE 1: LIST OF IN-VITRO ANTICANCER ACTIVITIES OF DIFFERENT PLANT EXTRACTS

S. no. Plant Family Part of Plant Used Specific Cancer Suppressed Reference
1 Aloe vera Asphodelaceae Whole plant HepG2 15
2 Annona muricata Annonaceae Leaves EACC, MDA and SKBR3 16
3 Annona squamosa Annonaceae Flower MCF-7 17
4 Arbutus

andrachne

 Ericaceae Aerial parts MCF-7, T47D, CACO-2, HRT18, A375.S2 and WM1361A 18
5 Aristolochia longa Aristolochiaceae Roots VCREMS 19
6 Aristolochia

ringens

 Aristolochiaceae Roots HCT-116, A431, A549, PC3, THP-1 and HeLa 20

 
7 Asplenium nidus Aspleniaceae Whole plant HepG2 and HeLa 21
8 Averrhoa bilimbi Oxalidaceae Fruit, leaves MCF-7 22
9 Azadirachta indica Meliaceae Leaves, seeds EACC 23
10 Barleria grandiflora Acanthaceae Leaves A-549 and DLA 24
11 Beberis aristata Berberidaceae Root, stem Colo 205, Hop 62,HT 29, SiHa, MIA-PA-CIA-2, DWD, T 24, PC 3, A549, ZR 75-1, A 2780, DU 145, MC F7 and K 562 25, 26
12 Caesalpinia sappan Caesalpiniaceae Hear wood, leaves MCF7 and A549 cell lines 27
13 Calligonum comosum Polygonaceae Whole plant HepG2 15
14 Cedrus

deodara

 Pinaceae Wood Colo 205, Hop 62,HT 29, SiHa, MIA-PA-CIA-2, DWD, T 24, PC 3, A549, ZR 75-1, A 2780, DU 145, MC F7 and K 562 25
15 Cenchrus ciliaris Poaceae Aerial parts, roots hepG-2, CACO, and A-549 28
16 C. antiochia var. praealta Asteraceae Aerial parts Vero and HeLa 29
17 Centaurea nerimaniae Asteraceae Aerial parts Vero and HeLa 29
18 Chrysanthemum coronarium Asteraceae Aerial parts MCF-7, T47D, CACO-2, HRT18, A375.S2 and WM1361A 18
19 Cocculus hirsutus Menispermaceae Aerial parts MCF-7 30
20 Corda dichotoma Boraginaceae Leaves PC3 31
21 Cotynus coggygria Anacardiaceae Leaves Vero and HeLa 29
22 Crataegus microphylla Rosaceae Leaves Vero and HeLa 29
23 Croton caudatus Euphorbiaceae Leaves DL, MCF-7, and HeLa 32
24 Curcuma longa Zingiberaceae Rhizome HL-60, HeLa 33
25 Delphinium staphisagaria Ranunculaceae Seeds H5-6 and N2A 19
26 Dillenia pentagyna Dillenaceae Stem bark DL, MCF-7 and HeLa 32
27 Euphorbia tirucalli Euphorbiaceae Leaves, stem Mia-PaCa2 34
28 Ficus beecheyana Moraceae Roots HL-60 35
29 Ficus carica Moraceae Fruit, leaves, sap MCF-7, B16F10 and HeLa 12
30 Ficus racemosa Moraceae Fruit MCF-7 13
31 Helicteres isora Sterculiaceae Whole plant HeLa-B75, H-60, HEP-3B and PN-15 36
32 Hibiscus calyphyllus Malvaceae Aerial  parts HepG2 and MCF-7 37
33 Hibiscus deflersii Malvaceae Aerial parts HepG2 and MCF-7 37
34 Hibiscus micranthus Malvaceae Aerial parts HepG2 and MCF-7 37
35 Hypericum kotshcyanum Hypericaceae Aerial parts Vero and HeLa 29
36 Inula viscosa Compositae Flowers MCF-7 and Hep-2 38
37 Jasmium sambac Oleaceae Flowers MCF-7 and Hep-2 38
38 Lavandula angustifolia Lamiaceae Flowers MCF-7 and Hep-2 38
39 Leea indica Vitaceae Leaves DU-145 and PC-3 39
40 Limonium

densiflorum

 Plumbaginaceae Shoots human lung carcinoma A-549, colon adenocarcinoma DLD-1Cell lines 40
41 Luffa cylindrica Araceae Aerial parts MCF-7 and Hep-2 38
42 Manilkara zapota Sapotaceae Flower MCF-7 17
43 Mirabilis

jalapa

 Nyctaginaceae Aerial parts, roots, stems MCF-7 and

Hep-2

 38
44 Morus nigra Moraceae Leaves heLa 41
45 Narcissus tazetta Amaryllidaceae Aerial parts, fowers MCF-7 and Hep-2 38
46 Nepeta italica Laminaceae Aerial parts Vero and HeLa 29
47 Ocimum sanctum Laminaceae Leaves HFS-1080 42
48 Oldenlandia corymbosa Rubiaceae Leaves K562 43
49 Olea europaea Oleaceae Leaves MCF-7, B16F10 and HeLa 12
50 Olea europaea Oleaceae Leaves Vero and HeLa 29
51 Ononis hirta Fabaceae Aerial parts MCF-7 and Hep-2 38
52 Ononis sicula Fabaceae Aerial parts MCF-7 and Hep-2 38
53 Origanum sipyleum Laminaceae Aerial parts Vero and HeLa 29
54 Parthenium hysterophorus Asteraceae Leaves K562 43
55 Phagnalon rupstre Asteraceae Aerial parts MCF-7 and Hep-2 38
56 Phyllanthus  emblica Phyllanthacae Leaves, fruit HT-29 44
57 Picrorhiza

kurroa

 Picrorhiza Root Colo 205, Hop 62,HT 29, SiHa, MIA-PA-CIA-2, DWD, T 24, PC 3, A549, ZR 75-1, A 2780, DU 145, MC F7 and K 562 25
58 Piper

longum

 Piperaceae Fruit Colo 205, Hop 62,HT 29, SiHa,

MIA-PA-CIA-2 DWD, T 24, PC 3, A549, ZR 75-1, A 2780, DU 145, MC F7 and K 562

 25
59 Piper

regnelli

 Piperaceae Leaves UACC-62, MCF7, 786-0, NCI-H460, PC-3, OVCAR-3, HT29 and K-562 45
60 Plectranthus

stocksii

 Lamiaceae Leaves, stem MCF-7, RAW 264.7 and Caco-2 cell lines 11
61 Populous alba Salicaceae Flowers MCF-7 and Hep-2 38
62 Pterocephalus pulverulentus Dipsacaceae Aerial

parts

 MCF-7 and

Hep-2

 38
63 Rosa damascena Rosaceae Flowers Vero and HeLa 29
64 Rosa damascene Rosaceae Receptacles

seeds

 MCF-7 and Hep-2 38
65 Saliva pinardi Labiatae Aerial parts MCF-7 and Hep-2 38
66 Salvia hypargeia Lamiaceae Aerial parts Vero and HeLa 29
67 Salvia officinalis Lamiaceae Leaves, stems MCF-7, B16F10 and HeLa 12
68 Saururus chinensis Saururaceae Roots MCF-7 46
69 Scorzonera tomentosa Asteraceae Aerial parts Vero and HeLa 29
70 Senecio scandens Asteraceae Leaves DL, MCF-7 and HeLa 32
71 Solanum khasianum Solanaceae Fruit DL, MCF-7 and HeLa 32
72 S. cretica subsp. vacillans Laminaceae Aerial parts Vero and HeLa 29
73 Syringa vulgaris Oleaceae Aerial parts, seeds MCF-7 and Hep-2 38
74 Syzygium cumini Myrtaceae Seeds A2780, MCF7, PC-3 and H460 47
75 Tabernaemontana divaricata Apocynaceae Flowers NIH 3T3 and

HeLa

 48
76 Tecoma stans Bignoniaceae Leaves, flowers A549 49
77 Terucrium

polium

 Laminaceae Leaves, stems,

aerial parts

 MCF-7, B16F10 T47D, CACO-2, HRT18, A375.S2  WM1361A, Hep-2 and HeLa 12, 38
79 Teucrium polium Laminaceae Aerial parts MCF-7, 18
80 Teucrium sandrasicum Lamiaceae Aerial parts Vero and HeLa 29
81 Tillandsia recurvata Bromeliaceae Whole plant A375, MCF-7 and PC-3 14
82 Verbascum sinaticum Scrophulariaceae Flowers, aerial parts MCF-7 and Hep-2 38
83 Vitis vinifera Vitaceae Liquid sap of stem MCF-7, B16F10 and HeLa 12
84 Withania

coagulants

 Solanaceae Root, leaves, stalk, Fruit HeLa, MCF-7, RD, RG and

INS-1

 50
85 Withania

somnifera

 Solanaceae Root Colo 205, Hop 62,HT 29, SiHa, MIA-PA-CIA-2, DWD, T 24, PC 3, A549, ZR 75-1, A 2780, DU 145, MC F7 & K 562 25
86 Zea mays Gramineae Leaves Hep2 51

CONCLUSION: In this review paper, the anticancer properties of various plants were analyzed in a broad spectrum. From this analysis, it is well understood that even locally available plants which all come across in day-to-day life can cure many deadly diseases and capacity to cure many deadly diseases and disorders. The in-vitro anticancer analysis is the basic step for identification of the anticancer potentials of the plants. Followed by the in-vitro studies, further studies such as preclinical and clinical studies can be carried out in detail. In the future, by understanding the importance of these plants and by utilizing their properties, further research can be carried out for drug discovery to reduce the viability of diseases.

ACKNOWLEDGEMENT: We acknowledge the support of Department of Biotechnology, Adhiyamaan College of Engineering, Hosur, Tamil Nadu, India.

CONFLICT OF INTEREST: The authors declared no conflict of interest.

REFERENCES:

  1. Fadeyi SA, Fadeyei OO, AAdejumo A, Okoro C and Myles EL: In-vitro anticancer screening of 24 locally used Nigerian medicinal plants. BMC Complementary and Alternative Medicine 2013; 13: 79.
  2. Rahman AHMM: A review of medicinal plants with anticancer activity in Bangladesh. Modern Applications in Pharmacy & Pharmacology 2018; 1(4): 000516.
  3. Chavan SS, Damale MG, Shamkumar PB and Pawar DP: Traditional medicinal plants for anticancer activity. International Journal of Current Pharmaceutical Research 2013; 5(4): 50-54.
  4. Manivel G, Kandasamy CS, Hariprasad R, Baskar K, Jegadeesh S and Venkatanarayanan R: Review on anticancer activity of medicinal plants. International Journal of Advance. Ideas and Innovations in Technology 2017; 3(3): 1024-28.
  5. Solowey E, Lichtenstein M, Sallon S, Paavilainen H, Solowey E and Lorberboum-Galski H: Evaluating medicinal plants for anticancer activity. The Scientific World Journal 2014; 1-12.
  6. Singh N, Mathur C, Sase NA, Rai S and Abraham J: Pharmaceutical properties of Emblica officinalis and Phyllanthus Emblica Research Journal of Pharmaceutical, Biological and Chemical Sciences 2015; 6(1): 1007-16.
  7. Kaur R, Singh J, Singh G and Kaur H: Anticancer plants: A review. J Nat Prod Plant Resour 2011; 1(4): 131-36.
  8. Merina N, Chandra KJ and Jibon K: Medicinal plants with potential anticancer activity: A review. International Research Journal of Pharmacy 2012; 3(6): 26-30.
  9. Garg A, Darokar MP, Sundaresan V, Faridi U, Luqman S and Rajkumar S: Anticancer activity of some medicinal plants from high altitude evergreen elements of Indian Western    The Journal of Research and Education in Indian Medicine in 2007; 13: 1-6.
  10. Umadevi M, Sampath Kumar KP, Debjit B and Duraivel S: Traditionally used anticancer herbs in India. Journal of Medicinal Plants Studies 2013; 1(3): 56-74.
  11. Muniyandi K, George E, Mudidli V, Kalagatur NK, Anthuvan AJ and Krishna K: Antioxidant and anticancer activities of stocksii Hook. f. leaf and stem extracts. Agriculture and Natural Resources 2017; 51: 63-73.
  12. Alzeer J, Vummidi BR, Arafeh R, Rimawi W, Saleem H and Luedtke NW: The influence of extraction solvents on the anticancer activities of Palestinian medicinal plants. Journal of Medicinal Plant Research 2014; 8(8): 408-15.
  13. Gavhane DS, Moreganokar SD and Mhase AK: Cytotoxic and anticancer activity of racemosa fruit extracton MCF7 human breast cancer cell line by SRB method. Journal of Animal Research 2016; 6(1): 43-7.
  14. Lowe HIC, Toyang NJ, Watson C, Badal S, Bahado-Singh P and Bryant J: In-vitro anticancer activity of the crude extract and two dicinnamate isolates from the Jamaican Ball Moss (Tillandsia recurvata) 2013; 3(1): 93-6.
  15. Shalabi M, Khilo K, Zakira MM, Elsebaei MG, Abdo W and Awadin W: Anticancer activity of Aloe vera and Calligonum comosum extracts separately on hepatocellular carcinoma cells. Asian Pacific Journal of Tropical Biomedicine 2015; 5(5): 375-81.
  16. Gavamukulya Y, Abou-Elella F, Wamunyokoli F and AEI-Shemy H: Phytochemical screening, anti-oxidant activity and in-vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata. Asian Pacific Journal of Tropical Medicine 2014; 7(1): S355-S363.
  17. Sumithra P, Gricilda Shoba F, Vimala G, Sathya J, Sankar V and Saraswathi R: Anti-cancer activity of Annona squamosa and Manilkara zapota flower extract against MCF-7 cell line 2014; 5(6): 98-104.
  18. Abu-rish EY, Kasabri VN, Hudaib MM, Mashalla SH, Al-Alawi LH and Tawaha KA: Evaluation of antiproliferative activity of some traditional anticancer herbal remedies from Jordan. Tropical Journal of Pharmaceutical Research 2016; 15(3): 469-74.
  19. Daoudi A, Amal EL, Youbi HEL, Bagrel D and Aarab L: In-vitro anticancer activity of some plants used in Moroccan traditional medicine. Journal of Medicinal Plants Research 2013; 7(17): 1182-89.
  20. Akindele AJ, Wani Z, Mahajan G, Sharma S, Aigbe FR and Sati N: Anticancer activity of Aristolochia ringens (Aristolochiaceae). Journal of Traditional and Complementary Medicine 2015; 5(1): 35-41.
  21. Jarial R, Thakur S, Sakinah M, Zularisam AW, Sharad A and Kanwar SS: Potent anticancer, antioxidant and antibacterial activities of isolated flavonoids from Asplenium nidus. Journal of King Saud University- Science 2018; 30: 185-92.
  22. Nair MS, Soren K, Singh V and Boro B: Anticancer activity of fruit and leaf extracts of Averrhoa bilimbi on MCF-7 Human breast cancer cell lines: A preliminary study. Austin Journal of Pharmacology and Therapeutics 2016; 4(2): 1082.
  23. Amer H, Helmy WA and Taie HAA: In-vitro antitumor and antiviral activities of seeds and leaves neem (Azadirachta indica) extracts. International Journal of Academic Research 2010; 2(2): 47-51.
  24. Manglani N, Vaishnava S, Dhamodaran P and Sawarkar H: In-vitro and in-vivo anti-cancer activity of leaf extract of grandiflora. International Journal of Pharmaceutical Sciences 2014; 6(3): 70-2.
  25. Gaidhani SN, Singh A, Kumari S, Lavekar GS, Juekar AS and Sen S: Evaluation of some plant extracts for standardization and anticancer activity. Indian Journal of Traditional Knowledge 2013; 12(4): 682-87.
  26. Serasanambati M, Chilakapati SR, Manikonda PK and Kanala JR: Anticancer activity of methanolic extract of Berberis aristata in MCF-7 human breast cancer cell lines. International Journal of Life Sciences Biotechnology and Pharma Research 2015; 4(1): 31-5.
  27. Bukke AN, Hadi FN, Babu KS and Shankar PC: In-vitro studies data on the anticancer activity of Caesalpinia sappan heartwood and leaf extracts on MCF7 and A549 cell lines. Data in Brief 2018; 19: 868-77.
  28. Alothman EA, Awaad AS, Al-Qurayn NA, Al-Kanhal HF, El-Meligy RM and Zain YM: Anticancer effect of Cenchrus ciliaris Saudi Pharmaceutical Journal 2018.
  29. Artun FT, Karagoz A, Ozcan G, Melikoglu G, Anil S and Kultur S: In-vitro anticancer and cytotoxic activities of some plant extracts on HeLa and Vero cell lines. Journal of the Balkan Union of Oncology 2016; 21(3): 720-5.
  30. Thakkar KN, Prasad AK, Nayak J, Iyer SV and Kumar S: Antioxidant and in-vitro cytotoxic activity of extracts of aerial parts of Cocculus hirsutus (L) using cell line cultures (breast cell line). The J of Phytopharmacology 2014; 3(6): 395-9.
  31. Rahman MA, Sahabjada and Akhtar J: Evaluation of anticancer activity of Cordia dichotoma leaves against a human prostate carcinoma cell line, PC3. Journal of Traditional and Complementary Medicine 2017; 7(3): 315-21.
  32. Rosangkima G and Jagetia GC: In-vitro anticancer screening of medicinal plants of Mizoram state, India, against Dalton’s lymphoma, MCF-7 and HeLa cells. International Journal of Recent Scientific Research 2015; 6(8): 5648-53.
  33. Srivatsava P and Srivatsava A: In-vitro anti-cancer activity of ethanolic extract of Cucurmin longa (turmeric) in Hep-2 cell lines. International Journal of Engineering Research and General Science 2015; 3(5): 495-08.
  34. Munro B, Vuong Q, Chalmers AC, Goldsmith CD, Bowyer MC and Scarlett CJ: Phytochemical, antioxidant and anti-cancer properties of Euphorbia tirucalli methanolic and aqueous extracts. Antioxidants 2015; 4: 647-61.
  35. Yen GC, Chen CS, Chang WT, Wu MF, Cheng FT and Shiau DK: Antioxidant activity and anticancer effect of ethanolic and aqueous extracts of the roots of Ficus beecheyana and their phenolic components. Journal of Food and Drug Analysis 2018; 26(1): 182-92.
  36. Shaikh R, Pund M, Dawane A and Iliyas S: Evaluation of anticancer, antioxidant, and possible anti-inflammatory properties of selected medicinal plants used in Indian traditional medication. Journal of Traditional and Complementary Medicine 2014; 4(4): 253-7.
  37. Alam P, Al-Yousef HM, Sidiqui NA, Alhowiriny TA, Alqasoumi SI and Aminal M: Anticancer activity and concurrent analysis of ursolic acid, β- sitosterol and lupeol in three different Hibiscus species (aerial parts) by validated HPTLC method. Saudi Pharmaceutical Journal 2018; 26(7): 1060-67.
  38. Talib WH and Mahasneh AM; Antiproliferative activity of plant extracts used against cancer in traditional medicine. Scientia Pharmaceutica 2010; 78: 33-45.
  39. Ghagane SC, Puranik SI, Kumbar VM, Nerli RB, Jalalpure SS and Hiremath MB: In-vitro antioxidant and anticancer activity of Leea indica leaf extracts on human prostate cancer cell lines. Integrative Medicine Research 2017; 6(1): 79-87.
  40. Medini F, Bourgou S, Lalancette KG, Snoussi M, Mkadmini K and Cote I: phytochemical analysis, anti-oxidant, anti-inflammatory and anticancer activities of the halophyte Limonium densiflorum extracts on human cell lines and murine macrophages. South African Journal of Botany 2015; 99: 158-64.
  41. Qadir MI, Ali M and Ibrahim Z: Anticancer activity of Morus nigra leaves extract. A Journal of the Bangladesh Pharmacological Society 2014; 9: 496-7.
  42. Karthikeyan K, Gunasekaran P, Ramamurthy N and Govindasamy S: Anticancer activity of Ocimum sanctum. Pharmaceutical Biology 1999; 37(4): 285-90.
  43. Pandey K, Sharma PK and Dudhe R. Anticancer activity of Parthenium hysterophorus and Oldenlandia corymbosa Lam. by Srb method. Open Access Scientific Reports 2012; 1(6): 1-3.
  44. Sumalatha D: Antioxidant and antitumor activity of Phyllanthus emblica in colon cancer cell lines. International Journal of Current Microbiology and Applied Sciences 2013; 2(5): 189-95.
  45. Longato GB, Rizzo LY, de Oliveira Sousa IM, Tinti SV, Possenti A and Figueira GM: In-vitro and in-vivo anti-cancer activity of extracts, fractions and Eupomatenoid-5 obtained from Piper regnelli Planta Med 2011; 77: 1482-88.
  46. Alaklabi A, Arif IA, Ahamed A, Kumar RS and Idhayadhulla A: Evaluation of antioxidant and anticancer activities of chemical constituents of the Saururus Chinensis root extracts. Saudi Journal of Biological Sciences 2017.
  47. Yadav SS, Meshram GA, Shinde D, Patil RC, Manohar SM and Upadhye MV: Antibacterial and anticancer activity of a bioactive fraction of Syzygium cumini seeds. HAYATI Journal of Biosciences 2011; 18(3): 118-22.
  48. Dantu AS, Shankarguru P, Ramya Devi D and Vedha Hari BN: Evaluation of in-vitro anticancer activity of hydroalcoholic extract of Tabernaemontana divaricate. Asian Journal of Pharmaceutical and Clinical Research 2012; 5(3): 59-61.
  49. Robinson JP, Suriya K, Subbaiya R and Ponmurugan P: Antioxidant and cytotoxic activity of Tecoma stans against lung cancer cell line (A549). Brazilian Journal of Pharmaceutical Sciences 2017; 53(3): 6.
  50. Maqsood M, Qureshi R, Ikram M, Ahmed S, Jabeen B and Asi MR: In-vitro anticancer activities of Withania coagulans against HeLa, MCF-7, RD, RG2 and INS-1 cancer cells and phytochemical analysis. Integrative Medicine Research 2018.
  51. Balasubramanian K and Padma PR: Anticancer activity of Zea mays leaf extracts on oxidative stree-induced Hep2 cells. Journal of Aquaculture and Meridian Studies 2013; 6(3): 149-58.

    How to cite this article:

    Saranya K, Manivasagan V, Kanakadurga R, Babu VPM and Babu NGR: A survey on anticancer properties of Indian medicinal plants - A broad spectrum analysis. Int J Pharm Sci & Res 2019; 10(8): 3635-40. doi: 10.13040/IJPSR.0975-8232.10(8).3635-40.

    All © 2013 are reserved by International Journal of Pharmaceutical Sciences and Research. This Journal licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

     

Article Information

14

3635-3640

730

1572

11

English

IJPSR

K. Saranya, V. Manivasagan, R. Kanakadurga, V. P. M. Babu * and N. G. R. Babu

Department of Biotechnology, Adhiyamaan College of Engineering (Autonomous), Hosur, Tamil Nadu, India.

vpmohanbabu1709@gmail.com

15 November 2018

17 February 2019

28 February 2019

10.13040/IJPSR.0975-8232.10(8).3635-40

01 August 2019

Download