A VALIDATED RP-HPLC METHOD FOR THE ESTIMATION OF ZOLEDRONIC ACID
AbstractA rapid and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of zoledronic acid in its pure form as well as in pharmaceutical dosage forms. Chromatography was carried out on an ODS C18column (250 x 4.6 mm x 5 m length),using a mixture of methanol and 0.01M phophate buffer (pH-3) (60:40 v/v) as the mobile phase at a flow rate of 0.8 mL/min and the detection was done at 210 nm. The retention time of the drug was 3.812 min. The method produced linear responses in the concentration range of 0.25 to 60 g/mL of zoledronic acid. The method was found to be reproducible for analysis of the drug in parentral preparations.
Article Information
25
826-829
454KB
3213
English
IJPSR
S. K. Mastanamma*, G. Suresh, D. Sindu Priya and J. V. L. N. Seshagiri Rao
M. Pharm., Ph. D., Associate Professor, D/o Shaik Moulali, D. No. 13/161, Tailors colony, Kothapet- 523155, Chirala, Prakasham (district), Andhra Pradesh, India
01 November, 2011
07 December, 2011
21 February, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(3).826-29
1-Mar-2012
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