A WAY OF COMBATING ANTIMICROBIAL RESISTANCE THROUGH QUORUM SENSING
AbstractQuorum sensing is a peculiar mechanism of microbial communication through the induction of various signalling autoinducer molecules having several gene expression regulatory activities of different virulence factors that control microbial. This enables a systematic path of inhibiting microbial growth and its infection production efficacy by indirectly regulating the Quorum sensing activity of the concerned pathogens. As antimicrobial resistance directly impacts the healthcare system, hence is one of the biggest threats to global health. The attenuation or inactivation of these resistant variety bacteria is the utmost call of hour. In this panorama, interference/change in the chemical signal of QS system has been developed as an efficient technique to block their expression, hence enabling them as less virulent. A literature study was performed using online research, including database searches such as PubMed, SciELO, and SCOPUS between 2000-2020. This review aims to provide a brief mechanism of inhibition of microbial resistance through QS system by different strategies.
Article Information
3
3833-3840
544
427
English
IJPSR
Shabnam Thakur *, Rupali Sharma and Rakesh Yadav
Amity Institute of Pharmacy, Amity University Haryana, Manesar, Gurgaon, Haryana, India.
sthakur233@gmail.com
18 January 2022
02 September 2022
08 September 2022
10.13040/IJPSR.0975-8232.13(10).3833-40
01 October 2022
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