ACUTE AND SUB-ACUTE TOXICITY STUDIES OF THE SIDDHA PREPARATION MV KASHAYAMIN WISTAR RATSAbstract
The acute and sub-acute toxicity analysis of Siddha preparation MV kashayam was carried out with Wistar rats as per the guidelines 423 and 407of the Organization for Economic Co‐operation and Development (OECD), respectively. In the acute toxicity study, a single dose of MV kashayam (1000 and 2000 mg/kg body weight) was administered orally to the rats and monitored for 14 days. In the sub-acute toxicity study, rats were orally administered with MV kashayam daily for 28 days at doses of 100 and 200 mg/kg body weight. In both the toxicity study, no rats have exhibited clinical signs of toxicity or mortality, and the doses were well tolerated by rats and no significant change in their mean body weight, food and water intake, haematological, biochemical parameters and his to pathological examinations as compared to that of control group rats. The findings suggest that MV kashayam has a wide margin of safety and a negligible amount of toxicity to ensure the safety and potency of the kashayam, which can be recommended to use as a novel prophylactic and therapeutic agent for COVID 19 based on the clinical study.
S. P. Malarkannan *, P Dharumarajan and Mkhariyohesh
Department of Rural Development Science, Arul Anandar College, Karumathur, Madurai, Tamil Nadu, India.
11 May 2021
08 June 2021
12 June 2021
01 February 2022