ADDRESSING THE GLOBAL THREAT OF ANTIMICROBIAL RESISTANCE: EMERGING APPROACHES, INNOVATIONS, AND RETHINKING STRATEGIES FOR FUTURE CONTROL

Antimicrobials are vital agents that combat dangerous microorganisms, but increasing resistance to these drugs is a major challenge to global health security. AMR occurs when the intended killing drugs lose their effectiveness because pathogens have learned how to adapt and become resistant to them mainly as a result of overusing, misusing or using antibiotics in ways that are not suitable. Adhering with this pressing matter necessitates fresh methods coupled with an all-inclusive perspective. Literature was searched through indexed databases including Scopus, PubMed, Google Scholar and Science director. Research on novel AMR treatments is continuing. Anti-virulent therapy targets bacteria’s virulence factors rather than eradicating them, preventing antibiotic-resistant strains. Naturally occurring or manufactured antimicrobial peptides have diverse modes of action and little resistance risk. Using antimicrobials to prevent infections reduces the need for curative antibiotics. Bacteriophage therapy employs viruses that infect and kill bacteria to treat illnesses. Plant derivatives like phytochemicals and nanoparticles are antimicrobial.Review addressing the challenge of antimicrobial resistance requirements and for multi-pronged approach, including surveillance, stewardship and development of new treatments. By implementing these approaches and fostering collaboration, current review focused on work towards sustainable solutions to protect public health and the utility of antimicrobial treatments. The time for action is now in order to mitigate the risk posed by AMR and ensure that our current arsenal of antimicrobials remains viable for future generations.