ADJUNCTIVE EFFECT OF LOCALLY DELIVERED MINOCYCLINE MICROSPHERES IN CHRONIC PERIODONTITIS: A SYSTEMATIC REVIEW

Objective: Chronic periodontitis, an inflammatory disease of the supporting tissues of teeth, is usually treated non-surgically by scaling and root planing. Minocycline is used as a local drug delivery and can be used as an adjunctive agent. The study aims to determine the efficacy of minocycline microspheres as a local drug delivery agent in treating chronic periodontitis. Methods: Randomized controlled trials investigating the efficacy of minocycline microspheres as local drug delivery agents in chronic periodontitis were included. Articles were retrieved from MEDLINE, EBSCO, Cochrane database, PUBMED, and Google Scholar in the English language from January 2000 up to January 2023. Articles retrieved were screened using specific inclusion criteria by four independent reviewers and analyzed using Rev Man 5.0 software. The measured outcomes were Probing Pocket Depth, Clinical Attachment Level, Plaque Index, and Gingival Index. Results: About 1288 patients aged above 30 were studied. In all the studies, the control group was treated with scaling and root planing alone, whereas the test group was treated with scaling and root planing followed by subgingival administration of minocycline microspheres. Scaling and root planing plus minocycline microspheres demonstrated better clinical outcomes than scaling and root planing alone. Conclusion: The present study shows that local delivery of minocycline microspheres significantly improves the clinical outcomes of traditional treatment and should be considered as an adjunct to scaling and root planing in chronic periodontitis.