ADVANCEMENTS AND FUTURE PERSPECTIVES IN OPHTHALMIC IN-SITU GEL: SMART DRUG DELIVERY FOR ENCHANCED OCULAR THERAPY
AbstractOcular in-situ gel systems are an improvised formulation in ocular drug administration, successfully addressing the limitations of standard eye drop formulations, such as low bioavailability and the necessity for frequent dosing. This review focuses on the formulation strategies, working mechanisms, and therapeutic applications of these gels in enhancing treatment outcomes. These systems rely on intelligent polymers that respond to physiological signals such as in temperature, pH, or ionic concentrations in the eye, convert from sol-to-gel, allowing for regulated release and prolonged drug residence time. The review delves into different polymer types, methods for drug incorporation, and factors that affect gelation behaviour. It also examines the latest developments limits that exist now and potential paths for the field. Special attention is given to preclinical and clinical evidence supporting the ability of in-situ gels to boost drug effectiveness, minimize adverse effects, and increase patient adherence. Overall, this detailed overview highlights the crucial role of ocular in-situ gels in the evolution of ophthalmic drug delivery systems.
Article Information
8
3248-3260
816 KB
5
English
IJPSR
Mohammed Lubna and Venu Madhav Katla *
Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal, Hyderabad, Telangana, India.
drkatla@stpaulscollege.ac.in
22 May 2025
23 June 2025
27 June 2025
10.13040/IJPSR.0975-8232.16(12).3248-60
01 December 2025
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