AMELIORATED ACTIVITY OF MURRAYA KOENIGII LEAVES CHLOROFORM EXTRACT (MKCE) AGAINST LEAD INDUCED HEPATIC DYSFUNCTIONS IN MICE

Lead is a well-known hepatotoxic and all-pervading heavy metal. Ingestion of lead induces structural dysfunctions, physiological distortion and biochemical impairment in the liver. The present study was aimed to ascertain the ameliorated effect of chloroform extract of Murraya leaves against the deleterious effects of lead on hepatic function parameters. Murraya koenigii Chloroform Extract (MKCE) was prepared by maceration. Male albino Swiss mice were divided into three groups of six each. Group I (Control group) served as normal diet and water ad libitum as control group, Group II (lead treated group) received intraperitoneal injection of lead acetate (15mg/kg) daily once whereas Group III (MKCE with lead-treated group) received MKCE (50 mg/kg) and injection of lead acetate intraperitoneally (15mg/kg) daily once time. Experimental study continued for consecutive 7 days. On the 8^th day, liver were desiccated from all animals; homogenized to collect supernatant into vials. Serum ALT, AST, ALP, TB, TP and ALB levels were estimated. Significant rise in levels of ALT, AST, ALP, TB were observed along with decreased level of TP and ALB in lead-intoxicated mice. Hepatic enzyme levels were significantly reduced (p<0.001) and augmented levels of protein and albumin in group III. Results in the study revealed significant hepatoprotective activity of MKCE against lead intoxication in mice by restoring all hepatic function markers to near normal level.