AMELIORATION OF INFLAMMATION AND CARDIOPROTECTIVE EFFECT OF TERMINALIA ARJUNA BARK EXTRACT IN HIGH-FAT DIET RAT MODEL
AbstractThe objective of this study is to investigate the protective effect of aqueous bark extract of Terminalia arjuna (TA) on high-fat diet-induced cardiovascular changes in Wistar rats using histological, immunohistochemical, and gene expression analysis. Group 1- without treatment served as control, group 2- High fat diet (HFD) received corn oil orally at a dose of 10 mL/kg, group 3 – HFD+atorvastatin (ATV) – 10 mg/kg, group 4 – HFD+TA125 mg/kg , and group 5- HFD+TA250 mg/kg, 6 days a week for 5 weeks. The activity of MMP-9 was measured in blood, Hematoxylin and Eosin staining was analyzed with heart tissue and TNF-α immunohistochemistry and ADIPOQ gene expression analysis were conducted using heart tissue. When Compared to the control group, the HFD group showed higher levels of MMP-9 activity and morphological changes in heart histology. TNF-α expression was also significantly increased in HFD group and down-regulation of ADIPOQ gene expression levels. MMP-9 activity and pathological damage to cardiac tissue including ADIPOQ gene expression were significantly reverted when T. arjuna bark extract was administered along with a high-fat diet. The findings reveal that T. arjuna bark has protective against HFD-induced cardiovascular alterations.
Article Information
31
340-348
1100 KB
556
English
IJPSR
Priya Palanivelu, Vijayakumar Jagadesan, Rajagopalan Vijayaraghavan, Senthilkumar Sivanesan * and Shree Mukilan Pari
Department of Research and Development, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
senbio@gmail.com
07 May 2022
17 June 2022
23 June 2022
10.13040/IJPSR.0975-8232.14(1).340-48
01 January 2023
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