AMELIORATIVE POTENTIAL OF BETULINIC ACID AND ROTUNDIC ACID ON NEPHROTOXICITY INDUCED BY MERCURY CHLORIDE IN RATS

Mercury toxicity is the most hazardous problem emerging in the world as its accumulation is escalating persistently through the increased utility of mercury in medicinal, industrial, and domiciliary usage. Subjection to mercury illustrates a consequential provocation to humans and other living biomes. The intention of the present research was to investigate the shielding potential of betulinic acid and rotundic acid against mercury chloride (HgCl₂) (1.29 mg/kg b. w.) induced renal toxicity in adult males rats. The examination was implemented in male albino wistar rats (n = 36). Which was partition into six gatherings as follows: Control, HgCl₂, HgCl₂ + betulinic acid, HgCl₂ + rotundic acid, betulinic acid alone, and rotundic acid alone. The results revealed that intense HgCl2 regulation modified different biochemical specifications incorporated with the elevated volume of lipid peroxidation (LPO) portion and a significantly depleted level of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) pursuits in the kidney tissue. Betulinic acid and rotundic acid is a natural antioxidant assist to safeguard oxidative injury by diminishing oxidative stress. In contrast, the treatment of betulinic acid and rotundic acid (5 mg/kg B. W) in the kidney tissue reveals a significant reduction in the degree of oxidant level and concurrently an elevated level of antioxidant properties via rehabilitation in kidney tissues. Oxidant substance (LPO), non-enzymatic antioxidant (GSH), and enzymatic antioxidants (GPx, SOD, CAT) reactions were additionally developed close to the normal (control) level when compared with mercury treated groups.