AN ANTIEPILEPTIC DRUGS FOR SEIZURE CONTROL IN EMERGENCY ROOM AND ASSESSMENT OF PATIENTS’ SATISFACTION TO ANTIEPILEPTIC MEDICATION IN TERTIARY CARE HOSPITAL

Background: Epilepsy is a common neurological disorder which results in significant morbidity. Epilepsy accounts for a significant proportion of the world’s disease burden, affecting around 50 million people worldwide. Aims: In this study, evaluate anti-epileptic drug for seizure control in Emergency room and effectiveness of various anti-epileptic drugs in terms of time to Seizure control. To assess the treatment satisfaction measured using the Treatment Satisfaction with Medicines Questionnaire (SATMED-Q). Materials & Methods: A Prospective observational study of 18 months duration carried out in patients presenting with seizure at Emergency department during the study period. The study began after the approval of study protocol by the Institutional Review Board. Statistical analysis was done using Microsoft Excel Office 2019 and rechecked with SPSS (version 25.0). P value <0.05 was considered as statistically significant. Result: Total 121 patients presented with seizure in Emergency, were recruited in the study during study period. About 98 patients completed the study and 23 were lost to follow-up. Out of 121 patients 80 (66%) were males and 41 (34%) were females. About 34 patients (28%) had focal seizures whereas 67 (55.37%) had generalized seizures. In our study, 24 patients received Inj. Lorazepam, and 22 patients received Inj. Midazolam among 46 patients who were active seizures. The time of seizure control was less who received Lorazepam as compared to Midazolam which statistically significant (p=<0.001). There was negative Pearson’s correlation between age and total score on followup. The correlation coefficient was -0.674 (p=<0.05) means with increase in age there was a decrease in total score. Conclusion: This is first kind of study in our setup to evaluate the drug used in emergency for seizure control and also evaluating effectiveness of drugs for seizure control in terms of time. Here, in this study as it has been shown that BZD like Lorazepam and Midazolam interrupt active seizure which reduces the chance of developing SE and improves outcomes. The study indicates an increasing trend toward clinical usage of newer AEDs as well as increasing trend of polytherapy. In our study, drugs were prescribed using generic names and brand name in equal proportion. Factors decreasing treatment satisfaction generally are low level education and older age. Our study indicated higher globally satisfaction with treatment in majority of the patients.