AN EXPERIMENTAL STUDY TO ASSESS THE MEMORY-ENHANCING PROPERTY OF PITAVASTATIN AND GEMFIBROZIL IN MICE USING THE MORRIS-WATER MAZE MODEL. EVIDENCE TO CATEGORIZE THEM AS SMART DRUGSAbstract
Introduction: Discovery of smart drugs is part of advancing the science of molecular and biochemical mechanisms of memory. Smart drugs are not just memory boosters; they also act as memory enhancers that help quick decision-making. Pitavastatin and gemfibrozil both cause lipid-lowering effects by different mechanisms of action. A few studies show they can act on CREB (c-AMP response elemental binding protein), a known transcription factor. CREB performs an essential role in long-term memory restoration. Aim and Objectives: To evaluate the memory enhancer effect of pitavastatin and gemfibrozil compared to piracetam using Balb-c mice. Material and Methods: The escape latency period and time spent in the target quadrant were compared among four groups. Observations were analyzed by using paired t-tests, ANOVA, and post hoc Tukey’s test. Results: Pitavastatin (30mg/kg) and gemfibrozil (60mg/kg) significantly decline in the escape latency period. pitavastatin increased the total time spent in the target quadrant as compared to vehicle control in the Morris-water maze test (p< 0.01). However, gemfibrozil fails to show any increment in spending time in the target quadrant. Conclusion: In the present study, we concluded that pitavastatin and gemfibrozil possess memory-enhancer properties and can define them as “smart drugs”. However, further studies are needed to confirm that hypothesis.
Shoebul Haque *, Ajit Mishra, Farah Asif, Rishi Pal, Narendra Kumar, Rajendra Nath, Amod Kumar Sachan and Rakesh Kumar Dixit
Department of Pharmacology and Therapeutics, King George’s Medical University, Lucknow, Uttar Pradesh, India.
09 August 2022
26 September 2022
23 October 2022
01 April 2023