AN OVERVIEW: MEDICINALLY IMPORTANT HETEROCYCLIC MOIETY BENZOTRIAZOLE
HTML Full TextAN OVERVIEW: MEDICINALLY IMPORTANT HETEROCYCLIC MOIETY BENZOTRIAZOLE
Hasit V. Vaghani *, Sarika P. Patel and Shweta A. Patel
Mehsana Urban Institute of Sciences, Ganpat Unversity, Kherva, Mehsana, Gujarat, India.
ABSTRACT: In organic chemistry, the largest families of organic compounds belong in the heterocyclic compounds. In our daily life, the importance of heterocyclic compounds is very essential. It has a broad range of applications in medicinal chemistry. Benzotriazole is a bicyclic heterocyclic system consisting of three nitrogen atoms and a fused benzene ring, shows wide range of biological and pharmacological activities. Benzotriazole has been a matter of discussion among the scientific community due to its potential characteristics and touched areas such as medicinal, pharmacological, industrial, etc. Benzotriazole derivatives have shown several pharmacological activities, which are antimicrobial activity, anti-inflammatory, analgesic activity, anticancer, antifungal, antibacterial, anticancer, anthelmintic, antidepressant, antioxidative, antitubercular, antiviral, anticorrosive, plant growth inhibitor, anti-inflammatory, etc.
Keywords: Benzotriazole, Antifungal, Antibacterial, Anticancer, Anticorrosive, Anti-inflammatory etc.
INTRODUCTION: Benzotriazole is coming from benzo-fused azoles are a class of heterocyclic compounds of great interest in the pharmaceutical and medicinal chemistry area. Benzotriazole has great characteristics in the context of electron-donating nature, group release, anion director in surrounding, etc. Benzotriazole is easy to introduce into molecules by a variety of addition, condensation, and substitution reactions. Benzotriazole comprises two fused rings; its five-membered rings can show tautomerism.
FIG. 1: ITS COMMON STRUCTURE IS STATED IN FIG. 1
FIG. 2: 3D MODEL OF THE BENZOTRIAZOLE MOLECULE
A synthesis of the Benzotriazole involves the following reaction: The reaction among the o-phenylenediamine, NaNO2 and CH3COOH will prepare the Benzotriazole 1. The conversion is done by diazotization of one of the amine groups 2. The synthesis is able to exist better by doing it in low temperatures 3 (5 to 10°C).
Product Specifications:
Molecular formula | : | C6H5N3 |
Molecular weight | : | 119.1240 |
Melting point | : | 98.5-100°C |
Appearance | : | White to Yellow Flakes |
Nature | : | White to brown crystalline powder |
Density | : | 1.36 g/cm3 |
Solubility in water | : | g/100 ml is 2 (moderate) |
pH | : | 5.5 to 6.5 |
CAS Registry Number | : | 95-14-7 |
UV absorbance | : | 286 nm |
Structure and Pharmacological Activities of Benzotriazole: The 1H-benzo[d] [1,2,3] triazole (Benzotriazole) Fig. 1 can be considered as a privileged structure for its several pharmacological activities. Useful as a scaffold for the design of new pharmacologically active compounds, Benzotriazole is undergoing rapid development in the synthesis of heterocyclic. From a purely chemical point of view, the benzotriazole structure proved extremely versatile applicabilities. For instance, it is currently used as a synthetic auxiliary 4-9.
In particular, it is interesting the use of the acylbenzotriazole methodology, developed by Katrizsky and co-workers 10. The N-acyl-benzotriazole is an easy-to-handle acylating agent for advantageous N-, O-, C- and S-acylations. Benzotriazole also acts as an electron-donor or a precursor of radicals or carbanions. It is easily insertable into other chemical structures through a series of reactions, such as condensation, addition reactions, and benzotriazolyl-alkylation 11-13. However, the main interest on Benzotriazole is focused in the pharmaceutical field, as suitably substituted benzotriazole derivatives can boast the most different biological properties, including plant growth regulator 14-17.
Benzotriazole and derivatives show diverse pharmacological activities on the basis of a variety of literature surveys.
Anticonvulsant activity, Anticancer, Antimicrobial activity, Antitubercular, Anti-inflammatory, Analgesic activity, Antifungal, Antibacterial, Anthelmintic, Antidepressant, Antioxidative, Antiviral, Anticorrosive, Plant growth inhibitor, Anti-inflammatory etc.
Application of the Benzotriazole Moiety in Drug Synthesis:
Anti-convulsant Activity: S D Srivastava and Co-workers 18. Synthesized a new series of 2-aryli-denylamino- 5- (N1 - benzotriazolomethyl)-1, 3, 4- thiadiazoles (4) and 1- [5’- (N1 benzotriazolo-methyl)- 1, 3, 4- thiadiazol-2’-yl]-4-(substituted phenyl)- 3- chloro-2-oxo-azetidines (5) derivatives Fig. 3. All the compounds were investigated for their anticonvulsant activities. Pentylene tetrazole were selected as standard.
FIG. 3: SHOW ANTICONVULSANT ACTIVITY
Below compound that shows good activity from all the compounds
R1 | R2 |
H | 2-OH-C6H4 |
H | 2-Cl-C6H4 |
H | -CH=CH-C6H5 |
C6H5 | C6H5 |
CH3 | C6H5 |
Anticancer Activity: Cancer is actually the second leading cause of death worldwide after cardiovascular diseases, accounting for about 8 million deaths. Viswanathan CL and Co-workers 19. New series were synthesized of the Benzotriazole derivatives Fig. 4. The entire compound was investigated for anticancer activity. Derivative designed and synthesized further to improve the chemosensitizing activity of the drug. The synthesized drug shows the 29.9% inhibition of the growth of the cells in murine lymphocytic leukemia cell, which was best than the standard drug Verapamil which inhibit 9.3% cell growth at 80 μg/mL concentration.
FIG. 4: SHOW ANTICANCER ACTIVITY
FIG. 5: SHOW ANTICANCER ACTIVITY
The above compound also show anticancer activity which is the benzotriazole derivative.
Anthelmintic Agent: Anthelmintis are a group of antiparasitic drugs that expel parasitic worms and other internal parasites from the body by either stunning or killing them and without causing significance damage to the host they may also be called vermicides. They affect the poorest and most deprived communities and are recognized as cause of chronic ill-health amongst the people living in tropical and subtropical areas 20. Benzotriazole derivatives effectively working as aanthelmintic agent. Benzotriazoles with 1- and 2-carbamoyl substituents give anthelmintic activity 21 Fig. 6.
FIG. 6: SHOW ANTHELMINTIC ACIVITY
FIG. 7: SHOW ANTHELMINTIC ACIVITY
R1 | R2 |
C6H6Cl | C6H6 |
C6H6Cl | C6H6NO2 |
C6H6Cl | C6H6Br |
FIG. 8: SHOW ANTHELMINTIC ACIVITY
In this connection, a series of benzotriazole-1-carbonyl-3, 5- arylformazans was synthesized by Sudhir et al., colleagues under ultrasonic and solvent free conditions. All compounds were tested for activity against adult earthworm Pheretima posthuma using mebendazole and albendazole as reference drugs.
Antimicrobial Activity: Infectious diseases raise awareness of our global unsafe, the need for strong health care systems, and the potentially broad and borderless impact of the disease. Over 9.5 million people die each year due to infectious diseases – nearly all live in developing countries.
Children are particularly at risk of infectious diseases. Pneumonia, diarrhea, and malaria are leading causes of death among children under age 5; cerebral malaria can cause permanent mental impairment.
Infectious diseases are also destructive to the health of adults, causing disability, a diminished quality of life co-infection. People infected with one infectious disease become more susceptible to other diseases. Examples include HIV/AIDS co-infection with tuberculosis or malaria co-infection with multiple neglected diseases. Some old infections are resurfacing, which is a really challenging task. Treatment of these infections with rapid resistance in organisms has added fuel to the worsened situation. Some viral infections like Dengue, Hepatitis, Japanese Viral, and West Nile Viral Infections cause large-scale deaths every year as epidemics. Pharmaceutical researchers have to keep in pace with these changes to control the infections by exploring newer anti-infective agents as much as possible. The ability of mankind to synthetically prepare medicinally important molecules during the past century has allowed for a continued decrease in the mortality rate from numerous diseases. The gravity of the situation made WHO resolve to focus on antimicrobial resistance and its global spread, particularly HIV/AIDS, tuberculosis, and malaria epidemics. These therapeutics agents bear wide range of structural differences and many of these compounds are having heterocyclic rings as their part structure. The literature survey reveals that heterocyclic compounds bearing benzotriazoles as part of the structure showed valuable biological activity particularly antibacterial and antifungal activity. Benztriazole derivatives have proven to be effective antimicrobials.
Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in-vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5, 6- dimethyl-1Hbenzotriazole and 5, 6-dibromo-1H- benzo-triazole have higher efficacy than the antiprotozoal agent chlorohexidine.
FIG. 9: DERIVATIVES OF ANTIMICROBIAL ACTIVITY
Analgesis Activity: Benzotriazole has immense properties work as an analgesic agent. An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain. Analgesic drugs act in various ways on the peripheral and central nervous systems. They are distinct from anaesthetics, which temporarily affect, and in some instances completely eliminate, sensation.
Asati KC et al., in 2006 Synthesised of 5-arylidene-2-aryl-3- (benzotriazoloacetamidyl)-1, 3-thiazolidin-4-ones as an analgesic and antimicrobial agents.
FIG. 10: SHOW ANALGESIC ACIVITY
Ar |
-NO2 C6H4 |
-Br C6H4 | |
-CH3 C6H4 | |
- Cl C6H4 |
Antioxidative Activity: Benzotriazole compounds have shown remarkable antioxidative activities and large potentiality to be novel antioxidative agents or candidates. Primaquine (PQ) derivatives are well-known and wide-used antimalarial drugs, meanwhile, they are interesting molecules to develop potential antioxidative agents due to their prooxidant effects in blood.
CM Jamkhandi and John Intru Disouza in (2013) Evaluate of antioxidant activity for some benzotriazole substituted with n-phenylacetamide and acetylcarbamic acid derivatives.
FIG. 11: SHOW ANTIOXIDATIVE ACTIVITY
FIG. 12: SHOW ANTIOXIDATIVE ACTIVITY
FIG. 13: SHOW ANTIOXIDATIVE ACTIVITY
FIG. 14: BENZOTRIAZOLES SUBSTITUTED WITH N-PHENYLACETAMIDE SHOWED HIGHER ANTIOXIDANT ACTIVITY THAN ANALOGUES SUBSTITUTED WITH ACETYLCARBAMIC ACID 22
Antituberculosis Activity: Tuberculosis (TB) is a highly infectious disease primarily caused by Mycobacterium tuberculosis. Multidrug-Resistant Tuberculosis (MDRTB) refers to M. tuberculosis strains with resistance to the two most effective antituberculosis drugs, isoniazid (INH) and rifampin (RFP). MDRTB has become a major barrier to achieving successful control of TB, as alternate therapy is less effective, associated with more adverse However, with the frequent occurrence of resistant strains and clinical adverse drug reactions of stomach and gut as well as liver damage, the uses of clinical antituberculosis drugs have been limited by the reduced efficacy and inevitable toxic side effects. Therefore, there is necessary to develop new potent anti-tubercular drugs without cross-resistance from known antimycobacterial agents. One of the most effective strategies to overcome this problem is to exploit the potentiality of standard short-course chemotherapy based on cheap and safe first-line drugs. Recently, more and more researches have shown that the nitrogen heterocyclic benzotriazole compounds have considerable potentiality to treat tuberculosis.
The substitution of benzotriazole ring by halogen atoms on the benzene ring has been proved to be a useful way to enhance the bioactivity of benzotriazole derivatives. Chlorine substituted benzotriazole derivative 23. It is worthy to note that when the chlorine atoms on the benzotriazole ring were replaced by other halogen atoms, the anti-mycobacterial activity markedly decreased. The nitro-substitution in the benzyloxy part of the molecule and the dichloro substituted benzotriazole resulted in its high biological activity.
Adesh Dubey et al., 2010 give different types of halogen, nitro contained compounds for antituberculosis activity. viz. Like Fig. 15, 16, 17.
FIG. 15: SHOW ANTITUBERCULOSIS ACIVITY
FIG. 16: SHOW ANTITUBERCULOSIS ACIVITY
FIG. 17: SHOW ANTITUBERCULOSIS ACIVITY
R1 | R2 |
Cl | H |
H | NO2 |
Antiviral Activity: Viruses can cause major diseases both in humans and animals and determine life lost economic losses and higher production costs. The current antiviral agents can not only inhibit the growth of the virus instead of directly destroying and killing them but also damage the host cell. For these reasons, large numbers of investigations have been focused on the design and development of non-nucleoside compounds as novel antiviral drugs in recent decades. The exploitation of new antiviral benzotriazole compounds has opened a new opportunity in this field.
Kuo-Long Yu, Yi Zhang synthesized benzotriazole derivatives as antiviral agents.
FIG. 18: SHOW ANTIVIRAL ACTIVITY
Avhad et al., synthesized a series of dialkylamino side-chain derivatives of benzotriazole were and reported as potential inhibitors of the respiratory syncytial virus.
FIG. 19: SHOW ANTIVIRAL ACTIVITY
Orthohantaviruses are classified as emerging viruses that cause two life-threatening diseases: hemorrhagic fever with renal syndrome (HFRS) and orthohanta viruses pulmonary syndrome (HPS), also known as hantavirus cardiopulmonary syndrome (HCPS) 24. Research group has published several 1(2)H-benzo[d][1,2,3]triazole, usually called benzotriazole, derivatives that have shown marked antiviral activity against many viruses 25-28.
The researcher performed the same broad antiviral screening on a series of 2-phenyl-benzotriazole from the library, or newly synthesized all showed in Fig. 20.
FIG. 20: SHOW ANTIVIRAL ACTIVITY
FIG. 21: SHOW ANTIVIRAL ACTIVITY
Antifungal Activity: During the past two decades, the frequency of invasive and systemic fungal infections has increased dramatically due mainly to Candida species. During the past two decades, the frequency of fungal infection increased dramatically due mainly to candida species 29. Recently, the expansion of antifungal drug research has occurred because there is a critical need for new antifungal agents to treat these life-threatening invasive fungal infections 30. Among different kinds of antifungal agents, azole compounds have been rapidly developed as the mainstream for fungal infection treatment and are widely used in clinic 31-33.
A variety of antifungal azoles representing as an important class of nitrogen-containing heterocycles with desirable electron-rich properties, have been early discovered and successfully used to develop clinical agents.
1-Carbamoyl-1H-benzotriazole (benzotriazole-1-carboxamide, 2a), an effective carbamoyl chloride substitute, and a range of its analogs can be synthesized in good yields in simple steps from 1,2-diaminobenzene.
Christopher John Perry et al., in 2008 gives different substituted of benzotriazole with good antifungal activity 35.
FIG. 22: SHOW ANTIFUNGAL ACIVITY
FIG. 23: SHOW ANTIFUNGAL ACIVITY
FIG. 24: SHOW ANTIFUNGAL ACIVITY
Ren Y, Zhang L, Zhou CH, Geng RX (2014) gives different metal complexes of benzotriazoles and exhibit a strong and typical property of action as bridging ligands metal ions, such as Ag(I) and Cu(II) ions. The Ag(I)- (triazole)-1-benzotriazole complex gives inhibitory effect against Physalospora piricola as well as good antifungal activity 35.
FIG. 25: SHOW ANTIFUNGAL ACIVITY
The Cu(Ⅱ) complex of benzotriazole derivative showed potentially antifungal activities against Penicillium expansum, Botrydepladia thiobromine etc.
FIG. 26: SHOW ANTIFUNGAL ACIVITY
CONCLUSION: This review gives an overview of the broad spectrum of pharmacological activities displayed by Benzotriazole. Benzotriazoles are regarded as an important class of bioactive hetero-cyclic compounds that exhibit a range of biological activities. Therefore, this nucleus appears very interesting in the drug discovery and development processes. As proved in this paper, benzotriazole is useful to wide develop analysis on different classes of pharmacological agents. Benzotriazole derivatives are focused on screening biological activities such as antibacterial, antiviral, antitubercular, anti-cancer, antimicrobial, antiinflammatory, anticonvul-sant, analgesic, antioxidant, etc. It can act as an important tool for medicinal chemists to develop newer compounds possessing benzotriazole moiety that could be better agents in terms of efficacy and safety.
ACKNOWLEDGEMENT: The authors are thankful to Mehsana Urban Institute of Sciences, Ganpat University, Mehsana, for providing library facilities and kind support for research work.
CONFLICTS OF INTEREST: The authors declare no competing financial interest.
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How to cite this article:
Vaghani HV, Patel SP and Patel SA: An overview: medicinally important heterocyclic moiety benzotriazole. Int J Pharm Sci & Res 2022; 13(1): 33-41. doi: 10.13040/IJPSR.0975-8232.13(1).33-41.
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IJPSR
Hasit V. Vaghani *, Sarika P. Patel and Shweta A. Patel
Mehsana Urban Institute of Sciences, Ganpat Unversity, Kherva, Mehsana, Gujarat, India.
hvv01@ganpatuniversity.ac.in
28 December 2020
12 May 2021
29 May 2021
10.13040/IJPSR.0975-8232.13(1).33-41
01 January 2022