AN UPDATED REVIEW ON ANALYTICAL METHODS FOR ESTIMATION OF AZELNIDIPINE

Hypertension is a ubiquitous and serious worldwide health concern, having a dramatic influence on individual health outcomes. In light of this rising worry, Azelnidipine, a third generation long-acting dihydropyridine calcium channel blocker, has emerged as a prospective therapeutic treatment. A vast body of research has indicated that Azelnidipine produces a strong antihypertensive impact, especially in individuals diagnosed with essential hypertension, thus validating its therapeutic usefulness in controlling this prevalent illness. This thorough study strives to give an in-depth overview of the numerous analytical techniques applied for the measurement of Azelnidipine. It covers a variety of techniques, including spectroscopic UV analysis, as well as chromatographic methods such as reversed-phase high-performance liquid chromatography (RP-HPLC), high-performance thin-layer chromatography (HPTLC), and ultra-performance liquid chromatography (UPLC), either alone or in combination with other drugs. These methodologies together give useful insights into the reliable measurement of Azelnidipine in pharmaceutical formulations. These techniques are tested for accuracy, precision, and resilience according to ICH criteria. They are excellent for both bulk medication and tablet dose forms because to their simplicity, sensitivity, and reproducibility. This study emphasizes the merits and limits of several analytical approaches for Azelnidipine, giving significant insights for researchers.