ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF CLITORIA TERNATEA LINN. LEAVES EXTRACT ON RAT MODEL
AbstractClitoria ternatea Linn is used both in traditional system and folk medicine to treat various inflammatory diseases such as arthritis and burns. The aim of the present study was to evaluate the analgesic and anti-inflammatory activity on scientific basis of different extracts of Clitoria ternatea Linnusing carrageenan-induced paw edema and tail flick method in rats respectively at various dose levels. From the results obtained among different extracts, only ethanol extract (400 mg/kg) showed maximum inhibition (23.80%) at 6th h and the early onset of action was found at 3rd h with only petroleum ether extract (400 mg/kg) showed statistical significant effect (p<0.001) compared to positive control group. Petroleum ether extracts (100 mg/kg, 200 mg/kg & 400 mg/kg) showed statistical significant inhibition from 4th to 6th h. In analgesic activity, both ethanol & petroleum ether extract showed the same type of effect but ethanol treated extract exhibited long lasting effect up to 2 h. The findings of the study proved justification of the use of the plant in the treatment of inflammatory conditions.
Article Information
41
600-606
373KB
2083
English
IJPSR
Manisha Bhatia, Jagbir Chahal and Sumeet Gupta*
Professor, Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana, Ambala, Haryana-133203, India
sumeetgupta25@gmail.com
30 September, 2013
18 December, 2013
15 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).600-06
01 February, 2014
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