ANALGESIC POTENTIAL OF HYDROGELS OF SILVER NANOPARTICLES USING AQUEOUS EXTRACT OF SARACA INDICA BARK

The present study reports analgesic potential of hydrogels of silver nanoparticles using Saraca indica bark extract makes a fast and convenient method for the synthesis of silver nanoparticles with the aid of microwave. The synthesized nanoparticles were characterized using UV-visible (UV-vis) spectrophotometer, Transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infra-red (FTIR) spectrometry. The nanoparticles were found to be spherical in shape and of 5 to 50 nm in size. The hydrogels of synthesized silver nanoparticles exhibited good analgesic activity. Testing was performed on the portion of the tail treated with hydrogels (control, aqueous extract of Saraca indica bark & silver nanoparticle using Saraca indica bark extract) and they were assessed using a fixed quantity of each drug. The tails were subjected to radiant heat two minutes after topical application since the analgesic actions of agents administered in this manner are restricted to the exposed part of the tail. Analgesic activity was checked by digital analgesiometer. Significant analgesic activity was observed with silver nanoparticles using Saraca indica bark extract when compared with control placebo and hydrogel prepared using Saraca indica bark extract and its activity was confirmed by tail flick method.