ANDROGRAPHOLIDES, THE ACTIVE PHYTOCHEMICALS OF THE MEDICINAL PLANT ANDROGRAPHIS PANICULATA & THEIR IMMUNOMODULATORY EFFECTS

Andrographolides are bioactive compounds derived from the plant Andrographis paniculata that have gained attention for their potential as an immune modulator. Research indicates that andrographolides exhibit anti-inflammatory, antioxidant, and immunomodulatory properties. It can enhance the activity of immune cells, such as macrophages and T lymphocytes, and modulate cytokine production, which helps balance immune responses. Clinical studies suggest that andrographolides may be beneficial in treating respiratory infections, reducing inflammation, and potentially providing protective effects against autoimmune conditions. Andrographolides have been shown to inhibit key inflammatory pathways, including the NF-κB, MAPK, and STAT3 signalling pathways, which play crucial roles in the immune response. Andrographolides have been studied in combination with conventional chemotherapy drugs, showing a synergistic effect that enhances the efficacy of chemotherapy while reducing side effects. While results are promising, more extensive clinical trials are necessary to establish its effectiveness and safety for long-term use. Andrographolides show potential as a natural immune-supportive agent, warranting further exploration in integrative health approaches.