ANTI-DIABETIC ACTIVITY OF METHANOLIC AND ETHYL ACETATE EXTRACTS OF WRIGHTIA TINCTORIA R.BR. FRUIT
AbstractThe present work was undertaken to investigate various extracts of fruit of Wrightia tinctoria (F-Apocyanacea) for anti-diabetic activity in alloxan induced diabetic rats. A comparison was made between the action of extracts and known anti-diabetic drug glibenclamide (10mg/kg body weight). Oral administration of methanolic extract at a dose of 300 mg/kg/b. wt and ethyl acetate extract at a dose of 200 mg/kg/b. wt exhibited a significant (p<0.001, p<0.001) hypoglycemic activity in normal rats and significant (p<0.001, p<0.001) anti-hyperglycemic activity in alloxan induced diabetic rats respectively. The maximum reduction in blood glucose level was observed after 4 hours in case of methanolic and ethyl acetate extracts with a percentage protection of 37% and 42% respectively. In long term treatment of alloxan induced diabetic rats the degree of protection was determined by measuring blood glucose on 0, 1, 2, 4, 7, 14th day. Both the extracts showed a significant anti-diabetic activity comparable with that of glibenclamide. These results indicate that the W. tinctoria fruit extracts possess significant anti –diabetic activity.
Article Information
46
3861-3866
543KB
1484
English
Ijpsr
M. Sandhya Rani* , Rao S. Pippalla , G. Krishna Mohan and M. Gangaraju
Centre for Pharmaceutical Sciences, Institute of Science and Technology, JNTU, Hyderabad, Andhra Pradesh, India
sandhya_uvts@yahoo.co.in
12 June, 2012
07 July, 2012
23 September, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3861-66
01 October, 2012
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