ANTI-DIABETIC ACTIVITY OF METHANOLIC AND ETHYL ACETATE EXTRACTS OF WRIGHTIA TINCTORIA R.BR. FRUITAbstract
The present work was undertaken to investigate various extracts of fruit of Wrightia tinctoria (F-Apocyanacea) for anti-diabetic activity in alloxan induced diabetic rats. A comparison was made between the action of extracts and known anti-diabetic drug glibenclamide (10mg/kg body weight). Oral administration of methanolic extract at a dose of 300 mg/kg/b. wt and ethyl acetate extract at a dose of 200 mg/kg/b. wt exhibited a significant (p<0.001, p<0.001) hypoglycemic activity in normal rats and significant (p<0.001, p<0.001) anti-hyperglycemic activity in alloxan induced diabetic rats respectively. The maximum reduction in blood glucose level was observed after 4 hours in case of methanolic and ethyl acetate extracts with a percentage protection of 37% and 42% respectively. In long term treatment of alloxan induced diabetic rats the degree of protection was determined by measuring blood glucose on 0, 1, 2, 4, 7, 14th day. Both the extracts showed a significant anti-diabetic activity comparable with that of glibenclamide. These results indicate that the W. tinctoria fruit extracts possess significant anti –diabetic activity.
M. Sandhya Rani* , Rao S. Pippalla , G. Krishna Mohan and M. Gangaraju
Centre for Pharmaceutical Sciences, Institute of Science and Technology, JNTU, Hyderabad, Andhra Pradesh, India
12 June, 2012
07 July, 2012
23 September, 2012
01 October, 2012