ANTI-HYPERGLYCEMIC ACTIVITY OF ETHANOLIC EXTRACT OF SOLANUM SURATTENSE ROOT
AbstractThe ethanol extract of Solanum surratense(EESS)(Family: Solanaceae) root was investigated for its anti-diabetic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of single dose of Alloxan monohydrate (150mg/kg). The ethanol extract of Solanum surratense at the dose of 200mg/kg and 400mg/kg, p.o. was administered as single dose per day to diabetes induced rats for a period of 21 days. The effect of EESS root on body weight of the animals, blood glucose, serum lipid profile [cholesterol, triglycerides], serum enzymes[serum glutamate oxaloacetate transamines(SGOT), Serum glutamate pyruvate transaminases(SGPT), alkaline phosphatase(ALP)], total protein were measured in the diabetic rats. EESS root elicited significant (p< 0.01) reductions of blood glucose, lipid parameters and serum enzymes and significant (p<0.01) reductions of blood glucose. From the above result, it is concluded that EESS root possesses significant anti-diabetic effects in Alloxan induced diabetic rats.
Article Information
44
2777-2781
324KB
992
English
IJPSR
Khumanthem Deepak Singh*, Sandipan Dass and Sunil Yadav
Guest Lecturer, Department of Pharmaceutical Sciences, Assam University, Assam, India
Guest Lecturer, Department of Pharmaceutical Sciences, Assam University, Assam, India
15 March, 2013
16 April, 2013
26 June, 2013
10.13040/IJPSR.0975-8232.4(7).2777-81
01 July, 2013
Download