ANTI-INFLAMMATORY ACTIVITY OF TRANS-CINNAMALDEHYDE AND PIPERINE COMBINATION AGAINST CARRAGEENAN INDUCED PAW EDEMA

Inflammation is one of the unique mechanism that help body to protect itself against burn, infection, allergens, toxic chemicals, or other noxious stimuli. It is a defense reaction of the body in order to eliminate or reduce the spread of injurious agent. However, over reaction of the body may be harmful or undesirable. This has resulted in extensive development of anti-inflammatory drugs. Despite the benefits that the drugs hold, it also carries the side effects such as gastric lesions, allergy reactions, tolerance and dependence, as well as resistance. Hence, researchers are working towards ideal medicines of anti-inflammatory with highest efficacy, best potency and lowest or none side effects. This research study evaluates the anti-inflammatory activity of trans-cinnamaldehyde and piperine combination. Preclinical testing of cinnamaldehyde and piperine was done earlier individually on inflammatory models but the combination was not validated for the treatment of inflammation. Therefore, the present study was carried out to evaluate the anti-inflammatory potential of the trans-cinnamaldehyde and piperine combination using carrageenan-induced paw edema model. The combination of trans-cinnamaldehyde and piperine exhibited significant anti-inflammatory activity which was comparable with the standard drug, indomethacin.