ANTI-INFLAMMATORY EFFECT OF THE MOLECULAR PECTIN COMPLEX WITH ACETYLSALICYLLIC ACID ON A MODEL OF CARRAGEENAN PAW EDEMA IN RATS
AbstractThe aim of this work is a comparison of anti-inflammatory properties of the molecular pectin complex with 10% acetylsalicylic acid (P-ASA) and acetylsalicylic acid (ASA) in equimolar doses on the model of carrageenan-induced paw edema of rats. The study was carried out on a total of 28 adult male Sprague Dawley rats at 7 months of age. 30 min after injection of 1% aqueous solution of carrageenan to the plantar aponeurosis, studied drugs were orally administered once at the doses of 10, 20, 40 mg/kg ASA and 100, 200, 400 mg/kg P-ASA. The severity of edema, pain sensitivity, leukocyte count, its subpopulation ratio and IL-1β, IL-6, IL-8, TNFα level were determined. Normality, t-test and Mann-Whitney tests were used for statistical analyses. The ulcerogenic effect of P-ASA (dose 400 mg/kg) is significantly less than that of ACA (dose 40 mg/kg). The analgesic effect of P-ASA is comparable to ASA at equimolar doses. The anti-edema effect of ASA at the doses of 10 and 20 mg/kg is more pronounced than that of P-ASA at equimolar doses. P-ASA contributes to normalization of blood leukocyte profile. P-ASA may be recommended to using as anti-inflammatory agent with low ulcerogenic properties.
Article Information
8
1581-1591
639
1131
English
IJPSR
A. B. Vyshtakalyuk *, K. N. Bushmeleva, O. A. Lenina, L. F. Gumarova, S. T. Minzanova, A. A. Parfenov, G. P. Belyaev, L. G. Mironova, E. V. Chekunkov and V. V. Zobov
Laboratory of Chemical-Biological Researches, A. E. Arbuzov Institute of Organic and Physical Chemistry - Subdivision of the Federal State Budgetary Institution of Science "Kazan Scientific Center of Russian Academy of Sciences", Kazan, Russia.
alex.vysh@mail.ru
28 May 2019
24 September 2019
30 November 2019
10.13040/IJPSR.0975-8232.11(4).1581-91
01 April 2020
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