ANTIBACTERIAL ACTIVITIES AGAINST PYOGENIC PATHOGENS
AbstractPyogenic infection refers to bacterial infection that leads to the production of pus. Antibiotics to treat these pyogenic bacterial infections are routinely prescribed, toxicity of which is serious threat and makes chemotherapy more difficult. Management of pyogenic infections consists of aspiration or surgical drainage followed by appropriate antibiotics. A total of 50 samples were examined, 36 bacterial strains were isolated, 20 Gram positive, Staphylococcus aureus (8), Staphylococcus epidermidis (7), Corynebacterium pyogenes (5) and 16 Gram negative, Escherichia coli (4), Pseudomonas aeruginosa (4), Neisseria meningitidis (4). Morphological and biochemical tests confirmed the isolated microorganisms. The study was carried out using in vitro Kirby Bauer’s disk diffusion method. The percentage resistance of different Gram positive isolates against different antibiotics, penicillin, amoxicillin, ofloxacin, cefazolin, cefuroxime, erythromycin, chloramphenicol, ciprofloxacin, azithromycin and tetracycline was C. pyogenes (76%), S. aureus (61.25%) and S. epidermidis (48.55%). Results for Gram negative bacteria, N. meningitidis (62.5%), E. coli (61.6%) and P. aeruginosa (52.28%), against norfloxacin, gentamycin, ofloxicin, cefixime, cefuroxime, amicacin, nalidixic acid, cefotaxime and ceftriaxone were also observed. Most of the isolates were resistant and some were moderately affected by different antibiotics for both Gram positive and Gram negative bacteria. The ability to inhibit the growth of bacterial isolates indicates effective use of antibiotics as antibacterial agents depending on their antimicrobial activity, efficacy in infections and low toxicity
Article Information
16
2974-2979
443KB
1504
English
IJPSR
Sujata Singh , Mayuri Khare , Rakesh Kumar Patidar , Swati Bagde , K.N. Sahare , Deepak Dwivedi and Vinod Singh*
Associate Professor, Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India
vsingh3@rediffmail.com
29 March, 2013
02 May, 2013
18 July, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(8).2974-79
01 August, 2013