ANTIBACTERIAL ACTIVITY, PHARMACOKINETICS AND MOLECULAR DOCKING OF PHYTOCHEMICALS FROM RICINUS COMMUNIS` LEAF EXTRACT

To evaluate the antibacterial activity, pharmacokinetics and molecular interaction of the compounds from Ricinus communis` leaf extract. Antibacterial activity was assessed by using the micro-dilution method. The chemical constituents of the methanolic leaf extract were assessed by using gas chromatography-mass spectrophotometry (GC-MS). The drug-like and toxicity properties of the phytocompounds were predicted by SwissADME and ADMET lab tools. AutoDock Vina was employed to investigate the binding strength of the ligand-receptor complexes. The extract displayed antibacterial activity with the lowest minimum inhibitory concentration of 1.56 mg/mL on Bacillus spizizenii (ATCC 6633). The GC-MS showed volatile compounds, namely hexadecanoic acid, methyl ester (0.62%), tridecanoic acid (0.76%), pentafluoro propionic acid, nonyl ester (0.85%), 10-octadecanoic acid, methyl ester (2.93%) and cis-vaccenic acid (94.84%). The compounds did not inhibit isomers of cytochrome P450 (CPY) (CYP 2D6 and CYP 3A4). They were all predicted to have drug-like properties as they adhered to the Lipinski Ro5. The compounds did not show to induce any hepatotoxic effects. The compounds revealed the docking scores in the range of -4.4 to -5.7 kcal/mol. R. communis has the potential to be utilized as a source of therapeutic drug-like compounds.