ANTIBIOTIC RESISTANCE: OVERVIEW AND MECHANISMSAbstract
Antibiotics have a well-documented efficacy in the treatment of established infections and as prophylactic agents in medically compromised patients. Antibiotics use is suggested to be a major risk factor for development of antibiotic resistance. Resistance to antimicrobials is emerging at an alarming rate that has reduced treatment options for nearly every pathogen infecting humans. Many bacteria now display a variety of mechanisms that help protect them during antimicrobial exposure. These include production of β-lactamases and cephalosporinases, alterations in penicillin-binding proteins, multidrug efflux pumps, transferable resistance to vancomycin, and mutations in genes encoding DNA gyrase. This article gives information about how bacteria develop antibiotic resistance, new era of antimicrobial therapeutics and new strategies to eliminate antibiotic resistance.
Sonia Bindu Pandra*, David Banji, Otilia J. F. Banji, Ranjith Kumar Aavula and Swetha Merugu
Nalanda College of Pharmacy, Hyderabad road, Nalgonda, Andhrapradesh, India
19 July, 2010
27 October, 2010
11 November, 2010
01 December, 2010