ANTIDEPRESSANT EFFECT OF IBANDRONATE ON DEPRESSION MODELS
AbstractThis study was designed to evaluate and compare the Antidepressant effect of Ibandronate with Amitriptyline on depression models in albino mice. Eighteen Swiss albino mice weighing 20-25 grams were selected and divided into three groups of six animals each. Group 1: Normal Saline- 0.5 ml, Group 2: Amitriptyline – 39 mg/kg, Group 3: Ibandronate 0.325 mg/kg administered orally every day for 30 days. Animals were subjected to a forced swim test, tail suspension test, and Locomotor activity test on 1st, 10th, 20th and 30th day of the experiment after 1 hour of drug administration. The forced swimming test and Tail suspension test detected the duration of immobility, whereas the Actophotometer test detected the influence of the drug on the Locomotor system. The data reveal that Ibandronate has an antidepressant action that did not differ significantly from Amitriptyline. Ibandronate a Bisphosphonate has shown an antidepressant effect on depression models in albino mice.
Article Information
29
2471-2475
503 KB
351
English
IJPSR
V. S. Harish Kumar *, Shravani D. Patil, A. N. Pradeep, B. E. Pradeep, M. S. Raghu Prasada, K. G. Shivashankaramurthy and L. J. Kiran
Department of Pharmacology, S. S. Institute of Medical Sciences and Research Centre, Davanagere, Karnataka, India.
harishkvspharma@gmail.com
23 February 2022
13 April 2022
23 May 2022
10.13040/IJPSR.0975-8232.13(6).2471-75
01 June 2022
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