ANTIDIABETIC EFFECT OF A COMPOUND ETHANOLIC EXTRACT OF ANNONA SQUAMOSA, ECLIPTA ALBA, & BUTEA MONOSPERMA IN EXPERIMENTAL ANIMALS

Type 2 diabetes is a chronic metabolic disease that has a significant impact on the health, quality of life, and life expectancy of patients, as well as on the health care system. Exercise, diet, and weight control continue to be essential and effective means of improving glucose homeostasis. Despite considerable progress in the treatment of diabetes by oral hypoglycemic agents, search for newer drugs continues because the existing synthetic drugs have several limitations. The herbal drugs with antidiabetic activity are yet to be commercially formulated as modern medicines, even though they have been acclaimed for their therapeutic properties in the traditional systems of medicine. The present study concise on the effect of a compound ethanolic extract of all three plant parts as leaf extract of Annona squamosa, leaf extract of Eclipta alba and leaf extract of Butea monosperma, on fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. All the concentration of compound extracts produced a significant antidiabetic activity at dose levels 1/5 of their lethal dosest.