ANTIDIABETIC POTENTIAL OF ETHANOLIC EXTRACT OF FLOWER OF PETUNIA HYBRIDA IN RODENT

The present work focused on preparing ethanolic extract of Petunia hybrida and evaluating its anti-diabetic potential in rats. The extraction of flowers was carried out using ethanol and the extraction yield was found to be 21.7% w/w. The total phenolic content of ethanolic extract of Petunia hybrida was found to be 39.18±1.46 GAE mg/g. The antidiabetic action of the extract was evaluated in terms of the effect of extract on body weight and serum glucose level. Other parameters like cholesterol and serum urea were also evaluated. The results revealed that the serum glucose levels were highly elevated by the administration of STZ in all the groups by day 7. In treatment groups III to V, the glucose levels dropped in comparison to group II and by the day 21, the levels reached almost the level of control group in group III and V. This indicates that the extract exhibits significant glucose lowering potential. Both SGOT and SGPT enzyme levels get elevated during liver damage which is more in diabetic rats. The results reveal a reduced levels of these enzymes in the EEPH treated rats. An increase in serum creatinine is associated with renal impairment in diabetes. The EEPH treatment was able to restore the levels of creatinine, suggesting a potential antidiabetic action.