ANTIDIARRHOEAL ACTIVITY, NITRIC OXIDE SCAVENGING AND TOTAL TANNIN CONTENT FROM THE BARK OF CERIOPS DECANDRA (GRIFF.) DING HOU
AbstractThe present study was designed to investigate the antidiarrhoeal, nitric oxide scavenging and total tannin content from the ethanolic extract of the bark of Ceriops decandra (Griff.) Ding Hou (Family: Rhizophoraceae). The ethanol extract at graded doses (200 & 400 mg/kg body weight) was investigated for antidiarrhoeal activity in term of reduction in the rate of defecation and consistency of faeces in castor oil induced diarrhoea. At the dose of 400 mg/kg body weight, the extract showed a significant anti-diarrhoeal activity showing 61.57% reduction in diarrhoea (P<0.05) comparable to that of standard drug loperamide 68.55%. Two complementary test systems, namely nitric oxide scavenging and total tannin contents were used for screening antioxidant activities. The ethanol extract showed maximum scavenging activity of 67.42 ±0.83% at 100 µg/ml, where as ascorbic acid at the same concentration exhibited 81.13±0.74% inhibition. The IC50 value for ethanolic extract was found fairly significant (63.59 μg/ml) while compared to the IC50 value of the reference standard ascorbic acid (36.81 μg/ml). The total tannin content was also quite significant and high in ethanolic extract (276.52 mg/g of tannic acid equivalent). The results of the present study confirm antidiarrhoeal activity, nitric oxide scavenging and total tannin content from the bark of Ceriops decandra, thus provide the scientific basis for the traditional uses of this plant as the modality for diarrhoea and other pathological conditions where free radicals are implicated.
Article Information
11
1306-1311
520KB
1154
English
IJPSR
Md. Hemayet Hossain*, Md. Musfizur Hassan , Ismet Ara Jahan , Ishrat Nimmi , and Amirul Islam
Senior Scientific Officer, Chemical Research Division, BCSIR Laboratories, Dhaka, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka-1205, Bangladesh
11 January, 2012
21 February, 2012
19 April, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(5).1306-11
01 May, 2012