ANTIHYPERLIPIDEMIC EFFECT OF REOSTO, A HERBOMINERAL FORMULATION IN TRITON INDUCED HYPERLIPIDAEMIC RATS
AbstractIn the present study, an aqueous extract from a marketed mineralo-herbal preparation Reosto was evaluated for its hypocholesterolaemic and hypertriglyceridemic activities using Triton WR-1339 induced hyper- lipidemic rats as experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton (200 mg/kg body weight). The animals were divided into control (CG), hyperlipidemic (HG), hyperlipidemic plus Reosto extract (200 mg/kg body weight) (HG + ReA), hyperlipidemic plus Reosto extract (400 mg/kg body weight) (HG + ReB) and hyperlipidemic plus Fenofibrate (HG + FF) treated groups. Intragastric administration of Reosto extract to the rats caused a significant decrease on their plasma lipid levels (quantified using enzymatic kits). In Fenofibrate treated rats, lipid parameters were significantly changed indicating that this aqueous extract may contain products that lower plasma lipid concentrations and may be beneficial in treatment of hyperlipidemia
Article Information
48
3028-3032
454
1146
English
Ijpsr
Meena K Yadav
Division of Pharmaceutical Chemistry, Department of Pharmacy, Saroj Institute of Technology & Management Ahimamau, Sultanpur Road, Lucknow- 226002, Uttar Pradesh, India
14 July, 2011
11 October, 2011
27 October, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(11).3028-32
01 November, 2011
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