ANTIHYPERLIPIDEMIC EFFECT OF TINOSPORA CORDIFOLIA EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS

The present study was aimed to evaluate the antihyperlipidemic effect of aqueous extract of stem of Tinospora cordifolia in streptozotocin induced diabetic and diet induced hyperlipidemic rats. Diabetes mellitus was induced in male albino Wistar rats by intraperitoneal injection of streptozotocin (45 mg/kg b.w.). Hyperlipidemia was induced in diabetic rats by feeding 0.5% cholesterol and 0.1% cholic acid on diet basis in arachis oil (10 ml/kg b.wt) orally throughout the experimental period and simultaneously, the treatment groups received T. cordifolia (100 and 200 mg/kg b.w.) orally for 14 days. Glibenclamide (600 µg/kg b.w) was used as a standard antidiabetic drug and atorvastatin (1.2 mg/kg b.w.) was used as a standard antihyperlipidemic drug. Serum glucose levels were determined at weekly intervals and serum cholesterol, triglycerides, HDL-C, creatine kinase and free fatty acids were analyzed at the end of the experiment. Aqueous extract of T. cordifolia at 200 mg/kg b.w. dose decreased serum glucose, cholesterol, triglycerides, creatine kinase, and free fatty acids to normal level when compared to that of standard drug. Thus the study revealed that the aqueous extract of T. cordifolia was found to have potential effective in controlling the diabetes associated hyperlipidemic conditions effectively