ANTIMALARIAL ACTIVITY AND TOXICITY EVALUATION OF THE ALKALOID-RICH FRACTION OF MOMORDICA CHARANTIA FRUITS
AbstractIntroduction: We investigated to an in-vitro and in-vivo evaluation of antimalarial and toxicity of the alkaloid-rich fraction of Momordica charantia fruits. Materials and Methods: In-vitro and in-vivo antimalarial activity tests of Plasmodium falciparum strain 3D7 culture were performed on Plasmodium berghei-infected mice using suppressive and prophylactic methods, and evaluation of fraction toxicity was conducted on zebrafish (Danio rerio). Results and Discussion: The study found that IC50 value of the in-vitro test was 0.17 ± 0.12 µg/mL and anti-malaria test using a suppressive and prophylactic method at a dosage of 100 mg/kg/day was found to inhibit parasites by 74 and 73%, respectively. The evaluation of toxicity by the use of zebrafish revealed abnormalities in the formation of the heart (51.28%) and yolk sac (51.28%). Conclusion: Alkaloid rich-fractions have powerful in-vitro and in-vivo antimalarial activity, but they have teratogenic effects that can inhibit the formation of the heart and yolk sac.
Article Information
58
2516-2522
680
1168
English
IJPSR
S. Abdillah *, Y. Farida, Kartiningsih, N. M. D. Sandhiutami and K. Mohamad
Department of Pharmacology, Faculty of Pharmacy, Pancasila University, Jl. Srengseng Sawah, Jagakarsa, South Jakarta, Indonesia.
syamsudin.abdillah@gmail.com
23 June 2018
01 April 2019
24 April 2019
10.13040/IJPSR.0975-8232.10(5).2516-22
01 May 2019
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