ANTISPASMODIC AND ANTHELMINTIC ACTIVITY OF NYCTANTHES ARBORTRISTIS LINN.Abstract
Antispasmodic activity of the ethanolic extracts of different parts of Nyctanthes arbortristis Linn. was estimated using guinea pig ileum preparation against acetylcholine. Anthelmintic activity was tested following the method described by Kailashraj and Kurup, using earthworm (Pheretima posthuma). The extracts exhibited antispasmodic activity, which was less than that of piperazine citrate. The ethanolic extracts were found to have concentration-dependent paralytic activity, whereas its seeds and flowers showed lethal effect on the worms. It was also observed that the paralytic and lethal effects of respective ethanolic extracts were potentiated by the presence of atropine. It reveals that the anthelmintic activity of the extracts is due to the inhibition of motility by relaxing and depressing responsiveness to contractile action of acetylcholine.
SANJITA DAS*, DINAKAR SASMAL, SAUMYA PRIYA BASU
Department of Pharmaceutical Technology, Noida Institute of Engineering and Technology*, Greater Noida, (U.P.), India
04 January, 2010
17 January, 2010
24 January, 2010
01 February, 2010