ANTITUMORIGENIC EFFECT OF VARIOUS PARTS OF FICUS RACEMOSA IN DALTON LYMPHOMA ASCITES TUMOR INDUCED SWISS ALBINO MICE

Medicinal plants play an important role in the development of potent therapeutic agents. In recent years there has been an increased interest in using of herbal medicines. To assess the antioxidative and antitumorigenic efficacy of methanolic extract of bark, fruits, and leaves of Ficus racemosa in Dalton Lymphoma Ascites tumors transplanted Swiss albino mice. The results showed that the cytotoxicity study by Trypan blue assay revealed the concentration-dependent cytotoxic activity of MEFrB, MEFrF, and MEFrL to DLA tumor cells with the fifty percent effective dose (ED₅₀) at 54 µg, 58 µg, and 60 µg, respectively. The MTT assay also showed the cytotoxic effect to DLA tumor cells at the concentration-dependent, and the ED₅₀ was found to be 40µg (MEFrB), 42 µg (MEFrF), and 46 µg (MEFrL) and indicated their antitumorigenic potential. Intraperitoneal transplantation of DLA tumor cells altered the antioxidant balance of the mice liver by significantly decreasing the activities of enzymic antioxidants (CAT, SOD, and GPx) and non-enzymic antioxidants (Vitamin A, E, and C). Administration and co-administration of all the three extracts individually and to DLA tumor-induced mice significantly enhanced the enzymic and non-enzymic antioxidants status in all treatment periods, and this was found to be more significant than that found in silymarin administration. It can be suggested that all three extracts of MEFrB can be recommended as antioxidative and antitumorigenic agents to individuals suffering from oxidative degenerative diseases and microbial infections.