ASSESSMENT OF BIOCHEMICAL PARAMETERS IN THE PATIENTS OF CORONARY ARTERY DISEASE WITH TYPE 2 DIABETES MELLITUS

Impaired carbohydrate and lipid metabolism with amplified oxidative stress are well recognized factors for Coronary artery disease (CAD) which is the major reason of mortality and morbidity all over world. The incident of CAD with type 2 diabetes mellitus (T2DM) is growing and they are predicted to be the biggest cause of death by 2020 in India. Therefore, the venture of the present study was to assess the association of hyperglycemia, oxidative stress, antioxidant enzymes, lipid profile and lipoprotein components in serum of CAD with T2DM patients as well as to compare the results with age-sex matched healthy human volunteers. Five hundred participants were enrolled for the present study, with their ages ranging from 37 to 57 years from OPD of medicine, Era’s Lucknow Medical College & Hospital, Lucknow, were attending OPD for routine medical checkup. Out of which two hundred fifty were clinically new diagnosed case of CAD with T2DM like hyperglycemia, angina pectoris and Myocardial infarction (MI), remaining two hundred fifty were healthy controls.  All biochemical assays were carried out by the standard kit methods. Participants were investigated for serum lipid profile, Lipoprotein constituents along with levels of lipid peroxide, reduced glutathione and antioxidant enzymes. A marked impairment in levels of lipid profile accompanied with increase in the lipids and apo-protein levels of serum β lipoproteins following decrease in lipid and protein constituents of α lipoprotein, serum reduced glutathione as well as level of antioxidant enzymes in CAD with T2DM patients in comparison to healthy human controls.