ASSESSMENT OF OXIDATIVE STRESS, ANTIOXIDANT ENZYMES AND LIPID PROFILE IN THE SUBJECTS OF CORONARY ARTERY DISEASE (CAD)

Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The incident of CAD is rising and they are predicted to be the biggest causes of death by 2020 in India. Therefore, the aim of the present study was to assess the association of oxidative stress, antioxidant enzyme and lipid status parameters in CAD patients and to compare the results age- sex matched healthy control in our community. Three hundred participants were enrolled for the present study, with their ages ranging from 40 to 60 years from Era’s Lucknow Medical College & Hospital, Lucknow. Out of which one hundred fifty were clinically new diagnosed case of coronary artery disease like angina pectoris and Myocardial infarction (MI), remaining one hundred fifty were healthy controls.  These participants were investigated for serum lipid profile i.e. total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL). High density lipoprotein (HDL) along with blood levels of TBARS and some antioxidant enzyme namely Catalase (CAT), Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Glutathione reductase (GSSH-reductase) level. There was significant rise in serum levels of TC, TG, LDL-cholesterol and significant decrease in HDL- Cholesterol in CAD patients as compared to healthy controls. There was a significant increase in serum MDA, and significant decrease in CAT, SOD, GPx, GSSH-Reductase in CAD patients as compared to healthy controls. These two independent risk factors can results in oxidative modifications of LDL that could lead to atherosclerotic lesions which is underlying cause of CAD. The CAD patients are consistently associated with disorder of lipid metabolism and imbalance in oxidative- anti- oxidative status in them.